INT274884

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.08
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dusp6) cytosol (Dusp6) cytoplasm (Dusp6)
Dusp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 126 99.24 Very High Very High Very High
agonist 60 98.24 Very High Very High Very High
Pain 18 96.68 Very High Very High Very High
Perioperative pain 6 90.76 High High
Endocannabinoid 18 82.08 Quite High
Cannabinoid receptor 36 75.00 Quite High
Analgesic 6 72.16 Quite High
Cannabinoid 36 64.88 Quite High
Neuropathic pain 24 64.16 Quite High
antagonist 60 63.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 138 99.24 Very High Very High Very High
Pain 30 96.68 Very High Very High Very High
Hypersensitivity 30 95.68 Very High Very High Very High
Alzheimer's Dementia 6 90.80 High High
Post Operative Pain 6 90.76 High High
Neuropathic Pain 42 89.32 High High
Neurological Disease 6 88.44 High High
Necrosis 18 75.16 Quite High
Cancer 18 74.80 Quite High
Nervous System Injury 54 24.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data together suggest that the induction of MKP-3 rather than MKP-1 is the mechanism by which JWH015 reduces p-ERK1/2 expression.
Positive_regulation (induction) of MKP-3
1) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.12
M), which completely inhibited the induction of both MKP-1 and MKP-3 by JWH015, induced a significant increase in p-ERK1 (1.14 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B) and p-ERK2 (1.12 ± 0.02 of LPS + JWH015 control group, p < 0.05; Figures 4A and 4B).
Positive_regulation (induction) of MKP-3
2) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0
Triptolide, which blocked both MKP-1 and MKP-3 induction by JWH015, increased p-ERK in parallel.
Positive_regulation (induction) of MKP-3
3) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.50 Pain Relevance 0.25
We propose that CBR2 activation induces these effects via MKP-3 induction.
Positive_regulation (induction) of MKP-3
4) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.70 Pain Relevance 0.66
These data suggest that the reduction of pro-inflammatory factors and microglial migration via MKP-3 induction is part of the mechanism of action of CBR2 agonists.
Positive_regulation (induction) of MKP-3 associated with inflammation and agonist
5) Confidence 0.05 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2704199 Disease Relevance 0.38 Pain Relevance 0.24
Our results showed that JWH015-induced ERK dephosphorylation depends on a MKP-3 increase, rather than MKP-1.
Positive_regulation (increase) of MKP-3
6) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.49 Pain Relevance 0.25

General Comments

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