INT274887

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.68
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 2
microglia 2
Cbr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 5 99.32 Very High Very High Very High
Peripheral nerve injury 30 98.96 Very High Very High Very High
agonist 50 98.04 Very High Very High Very High
Pain 15 97.28 Very High Very High Very High
Inflammation 105 96.72 Very High Very High Very High
antagonist 50 91.04 High High
Cannabinoid receptor 30 89.56 High High
allodynia 10 88.32 High High
Cannabinoid 30 87.88 High High
Neuropathic pain 20 87.60 High High
Disease Link Frequency Relevance Heat
Cancer 15 99.96 Very High Very High Very High
Necrosis 15 99.72 Very High Very High Very High
Hypersensitivity 25 99.60 Very High Very High Very High
Nervous System Injury 45 98.96 Very High Very High Very High
Pain 25 97.28 Very High Very High Very High
INFLAMMATION 115 96.72 Very High Very High Very High
Drug Induced Neurotoxicity 5 90.48 High High
Neuropathic Pain 35 88.32 High High
Frailty 10 79.28 Quite High
Diabetes Mellitus 5 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed that microglial CBR2 activation reduces TNF expression [11,16] and ERK dephosphorylation results in a significant reduction of TNF in primary microglia [21].
Negative_regulation (reduces) of Positive_regulation (activation) of CBR2 in microglia
1) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.40 Pain Relevance 0.32
CBR2 activation and p-ERK inhibition reduce microglial migration
Negative_regulation (reduce) of Positive_regulation (activation) of CBR2
2) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.18
Accordingly, in vitro CBR2 activation reduces tumor necrosis factor-?
Negative_regulation (reduces) of Positive_regulation (activation) of CBR2 associated with necrosis and cancer
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 1.38 Pain Relevance 0.66
The reduction of microglial TNF production by CBR2 activation may explain the antinociceptive effects of CBR2 agonists in rodent pain models.
Negative_regulation (reduction) of Positive_regulation (activation) of CBR2 associated with pain, agonist and antinociceptive
4) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.81 Pain Relevance 0.66
Using a rat paw incision or a peripheral nerve injury model we have previously shown that in vivo spinal CBR2 activation reduces glial reactivity, measured as a reduction in the expression of CR3/CD11b or ionized calcium-binding adaptor molecule 1 (Iba-1) in microglia [12,13].
Negative_regulation (reduces) of Positive_regulation (activation) of CBR2 in paw associated with nervous system injury and peripheral nerve injury
5) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 1.09 Pain Relevance 0.79

General Comments

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