INT274895

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
microglia 3
Cbr2 (Rattus norvegicus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.32 Very High Very High Very High
agonist 20 98.04 Very High Very High Very High
Peripheral nerve injury 12 97.76 Very High Very High Very High
Pain 6 97.28 Very High Very High Very High
allodynia 4 88.32 High High
Neuropathic pain 8 87.60 High High
Inflammation 42 86.80 High High
cytokine 4 85.76 High High
dexamethasone 2 64.40 Quite High
cINOD 2 63.48 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 10 99.60 Very High Very High Very High
Nervous System Injury 18 97.76 Very High Very High Very High
Pain 10 97.28 Very High Very High Very High
Neuropathic Pain 14 88.32 High High
INFLAMMATION 46 86.80 High High
Alzheimer's Dementia 2 41.64 Quite Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of microglial TNF production by CBR2 activation may explain the antinociceptive effects of CBR2 agonists in rodent pain models.
Positive_regulation (activation) of CBR2 Negative_regulation (reduction) of Gene_expression (production) of TNF associated with pain, agonist and antinociceptive
1) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.81 Pain Relevance 0.66
We confirmed that microglial CBR2 activation reduces TNF expression [11,16] and ERK dephosphorylation results in a significant reduction of TNF in primary microglia [21].
Positive_regulation (activation) of CBR2 in microglia Negative_regulation (reduces) of Gene_expression (expression) of TNF in microglia
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.40 Pain Relevance 0.32

General Comments

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