INT274899

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.67
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) RNA binding (Gtf3a)
nucleus (Gtf3a) intracellular (Gtf3a) plasma membrane (P2rx4)
Anatomy Link Frequency
dorsal horn 3
P2rx4 (Mus musculus)
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 2 97.76 Very High Very High Very High
Spinal cord 1 97.08 Very High Very High Very High
allodynia 10 92.44 High High
Brush evoked pain 15 89.48 High High
Sciatic nerve 1 85.24 High High
Neuropathic pain 11 75.04 Quite High
Inflammation 12 73.56 Quite High
Pain 18 72.12 Quite High
Lasting pain 11 50.00 Quite Low
Dorsal horn 1 24.80 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 19 99.64 Very High Very High Very High
Neuropathic Pain 38 92.44 High High
Injury 5 84.40 Quite High
INFLAMMATION 12 73.56 Quite High
Pain 35 72.12 Quite High
Hypersensitivity 6 60.56 Quite High
Inflammatory Pain 5 8.72 Low Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of P2X4R in microglia induces release of brain-derived neurotrophic factor [9,22,23], a factor that is crucial for producing aberrant excitability of dorsal horn neurons [9,24].
Positive_regulation (Stimulation) of P2X4R in dorsal horn Positive_regulation (induces) of Localization (release) of factor in dorsal horn associated with dorsal horn neuron
1) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.67 Pain Relevance 0.95

General Comments

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