INT27493

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 114
Total Number 116
Disease Relevance 56.89
Pain Relevance 44.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
NAc 6
neuronal 3
neurons 3
hippocampus 2
osteoblasts 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1630 100.00 Very High Very High Very High
Morphine 200 100.00 Very High Very High Very High
withdrawal 30 100.00 Very High Very High Very High
cocaine 24 100.00 Very High Very High Very High
long-term potentiation 8 100.00 Very High Very High Very High
Dopamine 56 99.98 Very High Very High Very High
narcan 23 99.98 Very High Very High Very High
lidocaine 9 99.98 Very High Very High Very High
Nucleus accumbens 95 99.90 Very High Very High Very High
ketamine 23 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 98 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Peptic Ulcer 1 100.00 Very High Very High Very High
Injury 234 99.88 Very High Very High Very High
Apoptosis 1729 99.82 Very High Very High Very High
Hypoxia 348 99.74 Very High Very High Very High
Spinal Cord Injury 162 99.70 Very High Very High Very High
Death 1151 99.68 Very High Very High Very High
Diabetes Mellitus 164 99.60 Very High Very High Very High
Cv Unclassified Under Development 266 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, ALCAR treatment impairs caspase 3 protease activity, as demonstrated by reduced levels of cleaved PARP.
Negative_regulation (impairs) of caspase 3 protease
1) Confidence 0.56 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17714181 Disease Relevance 1.38 Pain Relevance 0.54
This study shows that a therapeutic concentration of 2,6-diisopropylphenol can protect osteoblasts from SNP- and HP-induced cell insults, possibly via suppression of caspase-3 activities.
Spec (possibly) Negative_regulation (suppression) of caspase-3 in osteoblasts
2) Confidence 0.53 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15965091 Disease Relevance 0.74 Pain Relevance 0
However, 2,6-diisopropylphenol significantly decreased SNP- and HP-enhanced caspase-3 activities.
Negative_regulation (decreased) of caspase-3
3) Confidence 0.53 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15965091 Disease Relevance 0.92 Pain Relevance 0
2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation.
Negative_regulation (suppression) of caspase-3 in osteoblasts associated with stress and apoptosis
4) Confidence 0.53 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 15965091 Disease Relevance 0.65 Pain Relevance 0.10
MK-801 alone (0.1 mg/kg) produced neither a place preference nor a place aversion, but was able to completely block morphine-induced CPP.
Negative_regulation (block) of CPP associated with morphine
5) Confidence 0.44 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7566661 Disease Relevance 0 Pain Relevance 0.56
After 7 days, the number of caspase-3 and -9 positive neurons was more in the isoflurane group (P < 0.05).
Negative_regulation (number) of caspase-3 in neurons associated with isoflurane
6) Confidence 0.43 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14980940 Disease Relevance 1.22 Pain Relevance 0.90
CPP was not abolished by ketamine or scopolamine administration in the animals' home cages.
Neg (not) Negative_regulation (abolished) of CPP associated with ketamine
7) Confidence 0.43 Published 2008 Journal Behav Pharmacol Section Abstract Doc Link 18469538 Disease Relevance 0.13 Pain Relevance 1.21
Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats.
Negative_regulation (suppress) of CPP associated with morphine
8) Confidence 0.43 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15890338 Disease Relevance 0 Pain Relevance 0.43
However, gabapentin did not cause a decrease in the number of caspase-3 reactive cells.
Negative_regulation (decrease) of caspase-3 associated with gabapentin
9) Confidence 0.42 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872851 Disease Relevance 0.32 Pain Relevance 1.01
Furthermore, HFGP co-treatment decreased caspase-3/-9 activity.
Negative_regulation (decreased) of caspase-3
10) Confidence 0.42 Published 2008 Journal Food Chem. Toxicol. Section Abstract Doc Link 18809456 Disease Relevance 0.80 Pain Relevance 0.82
Intracerebroventricular administration of z-DEVD-fmk-a specific tetrapeptide inhibitor of caspase-3-before and after injury markedly reduced post-traumatic apoptosis, as demonstrated by DNA electrophoresis and TUNEL staining, and significantly improved neurological recovery.
Negative_regulation (inhibitor) of caspase-3-before associated with injury, apoptosis and intracerebroventricular
11) Confidence 0.41 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295387 Disease Relevance 0.84 Pain Relevance 0.34
Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity.
Negative_regulation (decreased) of CPP associated with eae and morphine
12) Confidence 0.38 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.21 Pain Relevance 0.99
Administration of scopolamine and ketamine, after reexposure to a drug-paired context, resulted in the disruption of morphine CPP, suggesting the potential effects of scopolamine and ketamine in disrupting memory associated with environmental cues and addictive drugs.
Negative_regulation (disruption) of CPP associated with ketamine and morphine
13) Confidence 0.38 Published 2008 Journal Behav Pharmacol Section Abstract Doc Link 18469538 Disease Relevance 0 Pain Relevance 1.11
During the reacquisition of morphine-seeking behaviour, rats in the shell and sham lesion groups regained their CPP, while the CPP in core lesion rats remained severely impaired.
Negative_regulation (impaired) of CPP in shell associated with morphine
14) Confidence 0.38 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652762 Disease Relevance 0.18 Pain Relevance 0.61
After surgery, a reduction of CPP scores to morphine was observed in all groups.
Negative_regulation (reduction) of CPP associated with morphine
15) Confidence 0.38 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652762 Disease Relevance 0.17 Pain Relevance 0.55
The results showed that (1) the morphine-induced CPP was significantly inhibited by 3 or 5 consecutive sessions, but not by single session of 2 Hz PES. (2) A test of spatial leaning and memory ability using the Morris water maze task revealed that 2 Hz PES per se exhibited a promoting, rather than a deteriorating effect on the ability of spatial memory. (3) 2 Hz PES by itself produced a moderate yet significant CPP.
Negative_regulation (inhibited) of CPP associated with morphine
16) Confidence 0.38 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15890338 Disease Relevance 0 Pain Relevance 0.54
Thus, naloxone attenuated the CPP induced by wheel running.
Negative_regulation (attenuated) of CPP associated with narcan
17) Confidence 0.38 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11274677 Disease Relevance 0 Pain Relevance 0.51
In animals with 80% reduction of 5-hydroxytryptamine content of the nucleus accumbens, D-amphetamine CPP was unchanged and morphine CPP was attenuated compared with controls.
Negative_regulation (attenuated) of CPP in nucleus accumbens associated with nucleus accumbens and morphine
18) Confidence 0.38 Published 1988 Journal Behav. Brain Res. Section Abstract Doc Link 2840924 Disease Relevance 0.07 Pain Relevance 0.61
In the present experiment, a dose of 4 mg/kg of naloxone completely blocked the CPP induced in females by paced mating.
Negative_regulation (blocked) of CPP associated with narcan
19) Confidence 0.37 Published 2001 Journal Behav. Neurosci. Section Abstract Doc Link 11770067 Disease Relevance 0 Pain Relevance 0.38
When diazepam was given with morphine during training, rats displayed a CPP for the environment paired with the two drugs.
Negative_regulation (displayed) of CPP
20) Confidence 0.37 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10958076 Disease Relevance 0 Pain Relevance 0

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