INT274937

Context Info Confidence 0.21 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.36

mitochondrion (Creb1) cell morphogenesis (Ephb2) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1) kinase activity (Ephb2)

Ephb2 (Mus musculus) Creb1 (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 84 92.56 c fibre 28 77.48 spinal dorsal horn 50 54.96 Dorsal horn neuron 1 50.00 nMDA receptor antagonist 3 22.00 Pain 7 17.84 Spinal cord 28 5.00 Sciatic nerve 13 5.00 nMDA receptor 7 5.00 Kinase C 6 5.00

Disease Link Frequency Relevance Heat Pain 7 17.84 Hyperalgesia 8 5.00 Neuropathic Pain 3 5.00 INFLAMMATION 2 5.00 Overdose 1 5.00 Targeted Disruption 1 5.00 Nervous System Injury 1 5.00 Nociception 1 5.00 Injury 1 5.00 Peripheral Arterial Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We further examined the effects of EphB2-Fc application and targeted mutation of the EphB1 receptor on HFS-induced phosphorylation of CaMKII, ERK and CREB proteins and c-Fos expression.

EphB2 Spec (examined) Regulation (effects) of Phosphorylation (phosphorylation) of CREB

1) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.36

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