INT27507

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 3.43
Pain Relevance 12.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
striatum 4
tail 1
neurons 1
brain 1
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 495 100.00 Very High Very High Very High
agonist 90 100.00 Very High Very High Very High
dopamine receptor 36 99.72 Very High Very High Very High
antagonist 55 99.70 Very High Very High Very High
Cannabinoid 65 99.64 Very High Very High Very High
depression 59 99.58 Very High Very High Very High
opioid receptor 12 99.34 Very High Very High Very High
Ventral tegmentum 63 99.06 Very High Very High Very High
narcan 8 98.76 Very High Very High Very High
tail-flick 2 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Catalepsy 7 99.88 Very High Very High Very High
Targeted Disruption 60 99.60 Very High Very High Very High
Depression 66 99.58 Very High Very High Very High
Sprains And Strains 21 99.40 Very High Very High Very High
Diarrhoea 6 99.08 Very High Very High Very High
Morphine Dependence 1 93.92 High High
INFLAMMATION 17 90.80 High High
Pain 7 87.84 High High
Stress 42 87.00 High High
Parkinson's Disease 20 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo dopamine D1 and D2 receptor occupancies of the six drugs to the striatum were observed.
Positive_regulation (occupancies) of D1 in striatum associated with dopamine
1) Confidence 0.44 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808703 Disease Relevance 0.47 Pain Relevance 0.17
However, in the striatum of intact adult animals, D1 dopamine agonists fail to induce c-fos expression.
Neg (fail) Positive_regulation (induce) of D1 in striatum associated with dopamine and agonist
2) Confidence 0.41 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.22
By day 21, as in adult animals, no more c-fos response to D1 agonists was observed, except in the most caudal division of the striatum.
Neg (no) Positive_regulation (response) of D1 in striatum associated with agonist
3) Confidence 0.41 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.40
The results showed that continuous infusion of clozapine increased the density of D1 but not D2 receptors.
Positive_regulation (increased) of D1
4) Confidence 0.40 Published 1995 Journal Biol. Psychiatry Section Abstract Doc Link 7619972 Disease Relevance 0 Pain Relevance 0.50
The c-fos response to D1 receptor activation in adults requires a previous sensitization of dopaminergic receptors by chronic treatment with reserpine or by lesion of the nigro-striatal pathway.
Positive_regulation (activation) of D1
5) Confidence 0.38 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.24
During a transient postnatal period, c-fos expression in a patchy distribution was induced by D1 receptor activation: only a faint response was detected on postnatal day 1, but islands of strong hybridization signals for c-fos mRNA in response to the D1 agonist were observed at postnatal day 3, with a progressive decrease in intensity from day 6 to day 15.
Positive_regulation (activation) of D1 associated with agonist
6) Confidence 0.38 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.37
Dopaminergic control of gene transcription during striatal ontogeny: c-fos induction by D1 receptor activation in the developing striosomes.
Positive_regulation (activation) of D1
7) Confidence 0.38 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.23
It may be postulated that D-1 receptor activation decreases, while D-2 receptor stimulation increases the antinociceptive effects of morphine.
Spec (postulated) Positive_regulation (activation) of D-1 associated with antinociceptive and morphine
8) Confidence 0.37 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2619426 Disease Relevance 0 Pain Relevance 1.27
Our data with local VTA infusion of the same antagonist confirms this requirement for D1 signaling.
Positive_regulation (requirement) of D1 associated with ventral tegmentum and antagonist
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013137 Disease Relevance 0 Pain Relevance 0.84
These results indicate that the antidepressant-like effect of melatonin in the tail suspension test is likely mediated by an interaction with the dopaminergic system, through an activation of dopamine D1 and D2 receptors.
Positive_regulation (activation) of D1 in tail associated with dopamine and antidepressant
10) Confidence 0.35 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20406627 Disease Relevance 0.09 Pain Relevance 0.97
It is concluded that activation of both dopamine D1 and D2 receptors may suppress naloxone-induced jumping in morphine-dependent mice, and that stimulation of dopamine D1 receptors during development of morphine dependence may increase diarrhoea through peripheral mechanism.
Positive_regulation (activation) of D1 associated with addiction, dopamine, diarrhoea, narcan and morphine
11) Confidence 0.31 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12242090 Disease Relevance 0.58 Pain Relevance 0.93
Deletion of the DA D1 receptor increased the responsiveness of enkephalin neurons to haloperidol, in that haloperidol-induced increases in c-Fos and catalepsy were enhanced in D1 receptor knockout mice.
Positive_regulation (enhanced) of D1 in neurons associated with targeted disruption, dopamine, catalepsy and enkephalin
12) Confidence 0.29 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.20 Pain Relevance 0.52
In contrast, the delta 2 agonist, DT-II, inhibited both D1 and A2a activated enzyme in all strains except DBA/2J, where DT-II did not inhibit D1-activated adenylyl cyclase.
Positive_regulation (activated) of D1 associated with agonist and sprains and strains
13) Confidence 0.22 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.33 Pain Relevance 0.79
Furthermore, these results suggest that the rewarding effects of delta 1 opioid receptor agonist may be produced through activation of the central dopaminergic system, especially dopamine D1 receptors, whereas the rewarding effects of delta 2 opioid receptor agonists may be produced by some other mechanism(s).
Positive_regulation (activation) of D1 associated with dopamine, agonist and opioid receptor
14) Confidence 0.20 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8740041 Disease Relevance 0 Pain Relevance 0.91
For example, activation of both D1 and D2 dopamine receptors is necessary to induce movement in conditions of dopamine deficiency [12].


Positive_regulation (activation) of D1 associated with dopamine and dopamine receptor
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.12 Pain Relevance 0.26
In the PrPFC, eCB-LTD did not require the activation of NMDAR, D1 or D2 dopamine receptors, as demonstrated by the lack of effects of a cocktail of antagonist of these receptors (Fig 5A).
Positive_regulation (activation) of D1 associated with depression, antagonist and dopamine receptor
16) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.80 Pain Relevance 0.75
Moreover, the stimulatory and the inhibitory effects of the cannabinoid agonist involved activation of dopamine D1 and D2 receptors, respectively [7].
Positive_regulation (activation) of D1 associated with dopamine, cannabinoid and agonist
17) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.13 Pain Relevance 0.57
Connor et al. [17] have shown that NPD1, resolvin D1, and resolvin E1 (all derivatives of ?
Positive_regulation (derivatives) of D1
18) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834569 Disease Relevance 0.45 Pain Relevance 0.18
Although not all DARPP-32 expressing neurons contain D1-like dopamine receptors, DARPP-32 is present in practically all D1-like receptor-containing neurons [56], and is generally regarded as a useful marker to determine where increased D1-like receptor activity is occurring within the brain.
Positive_regulation (increased) of D1 in brain associated with dopamine receptor
19) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
Additional evidence in rodents has suggested both D1-like and D2-like dopamine receptors, and
   the dopamine transporter gene may be a mediator in addictive behavior 53, 61, 155. 
Positive_regulation (suggested) of D1 associated with dopamine and dopamine receptor
20) Confidence 0.06 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.05 Pain Relevance 0.38

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