INT275071

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 106 99.66 Very High Very High Very High
Neurotransmitter 16 82.24 Quite High
depression 16 73.60 Quite High
Hippocampus 18 55.20 Quite High
Central nervous system 8 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 16 73.60 Quite High
Cognitive Disorder 188 60.20 Quite High
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Schizophrenia 12 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low
Shock 8 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, treatment of rodents with different types of selective PDE-Is, which inhibit the degradation of the second messengers cAMP and/or cGMP, improved their STM as well as LTM.
Negative_regulation (inhibit) of Protein_catabolism (degradation) of cGMP
1) Confidence 0.17 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.31 Pain Relevance 0.25
As presynaptic cGMP plays a role in E-LTP, theoretically, inhibition of cGMP degradation with, for instance, a PDE9-I should, therefore, be able to influence L-LTP/LTM via E-LTP/STM as well.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of cGMP associated with long-term potentiation
2) Confidence 0.16 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.05 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox