INT275085

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 9 70.72 Quite High
antidepressant 2 62.88 Quite High
long-term potentiation 53 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 7 96.12 Very High Very High Very High
Cognitive Disorder 94 94.72 High High
Schizophrenia 6 45.20 Quite Low
Targeted Disruption 15 41.68 Quite Low
Aging 6 40.68 Quite Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirdly, since most PDEs are transcribed by several genes, which give rise to multiple PDE splice variants and isoforms, further investigation into possible isoform-specific effects of PDE-Is is a field of great interest.
Transcription (transcribed) of PDEs
1) Confidence 0.04 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.27 Pain Relevance 0.16

General Comments

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