INT275090

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) cell differentiation (Twist1) signal transduction (Pde5a)
nucleus (Twist1) DNA binding (Twist1) transcription factor binding (Twist1)
Twist1 (Mus musculus)
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 53 87.52 High High
Hippocampus 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 99.76 Very High Very High Very High
Cognitive Disorder 94 95.68 Very High Very High Very High
Anxiety Disorder 12 82.52 Quite High
Pressure Volume 2 Under Development 2 45.44 Quite Low
Targeted Disruption 15 31.80 Quite Low
Schizophrenia 6 9.00 Low Low
Depression 8 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is because PDE-Is increase the levels of cAMP and cGMP, and vasodilatation properties can be attributed to both cyclic nucleotides (Dundore et al. 1993; Paterno et al. 1996).
PDE Positive_regulation (increase) of Gene_expression (levels) of cGMP associated with increased venous pressure under development
1) Confidence 0.02 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.62 Pain Relevance 0.04

General Comments

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