INT275097

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Twist1 (Mus musculus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 106 100.00 Very High Very High Very High
depression 16 92.24 High High
Glutamate 4 90.32 High High
Hippocampus 18 72.24 Quite High
nMDA receptor 4 47.44 Quite Low
Neurotransmitter 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 16 92.24 High High
Cognitive Disorder 188 58.32 Quite High
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Schizophrenia 12 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low
Shock 8 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since LTP is considered the underlying mechanism for learning and memory, it is relevant to evaluate the effects of PDE-Is on LTP in addition to and in parallel with behavioral studies.
PDE Regulation (effects) of LTP associated with long-term potentiation
1) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.37 Pain Relevance 0.66
Yet, only a limited number of studies has investigated the effects of PDE-Is on LTP.
PDE Spec (investigated) Regulation (effects) of LTP associated with long-term potentiation
2) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.30

General Comments

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