INT275147

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.94
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (CSTB) nucleus (CSTB) intracellular (CSTB)
cytoplasm (CSTB)
CSTB (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 50.04 Quite High
Inflammation 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
diclofenac 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 64 93.80 High High
Disease 16 75.80 Quite High
Deafness 7 67.12 Quite High
Rhabdomyolysis 4 58.40 Quite High
Mycobacterial Infection 2 57.84 Quite High
Gallstones 6 51.36 Quite High
Cv General 3 Under Development 1 41.52 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 23.44 Low Low
Infection 6 13.48 Low Low
Staphylococcus Infection 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But, a major question is sustainability, whether the CPI can maintain its momentum and substantively contribute to improved drug development.



CPI Binding (maintain) of
1) Confidence 0.04 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996064 Disease Relevance 0.13 Pain Relevance 0
This review discusses the various strategies adopted under CPI to decrease attrition rate and stagnation of new drug development, and the challenges and controversies associated with CPI.



CPI Binding (associated) of
2) Confidence 0.04 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Abstract Doc Link PMC2996064 Disease Relevance 0.15 Pain Relevance 0
If this similarity can be detected, we may infer that the CPI not only represent the binding situation of a drug to a protein, but also reflect the interacting character of it towards multi-protein set.
CPI Binding (binding) of
3) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 0.66 Pain Relevance 0.03

General Comments

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