INT275171

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Stat3, Rac1, Rac1, Stat3) cell proliferation (Stat3, Rac1, Rac1, Stat3) plasma membrane (Stat3, Rac1, Rac1, Stat3)
intracellular (Rac1, Rac1) enzyme binding (Rac1, Rac1) GTPase activity (Rac1, Rac1)
Anatomy Link Frequency
fibroblasts 3
Stat3 (Rattus norvegicus)
Rac1 (Rattus norvegicus)
Rac1 (Rattus norvegicus)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 47 72.20 Quite High
fibrosis 6 70.32 Quite High
Inflammatory response 7 5.00 Very Low Very Low Very Low
Inflammatory marker 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Arrhythmia 287 82.88 Quite High
INFLAMMATION 59 72.20 Quite High
Fibrosis 8 70.32 Quite High
Coronary Heart Disease 3 70.20 Quite High
Adhesions 3 31.76 Quite Low
Thrombosis 1 18.88 Low Low
Recurrence 28 5.00 Very Low Very Low Very Low
Myocardial Infarction 27 5.00 Very Low Very Low Very Low
Coronary Artery Disease 14 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In atrial myocytes, activation of STAT3 by Rac1 was mediated by direct association of Rac1 with STAT3; however, in atrial fibroblasts, it was mediated by an indirect paracrine effect.
STAT3 Binding (association) of Rac1 in fibroblasts Positive_regulation (mediated) of Rac1 Positive_regulation (activation) of STAT3 in fibroblasts
1) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704895 Disease Relevance 0.73 Pain Relevance 0.10

General Comments

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