INT275179

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 66.48 Quite High
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 32 86.92 High High
Hypoxia 1 86.64 High High
Breast Cancer 1 81.20 Quite High
Apoptosis 53 74.28 Quite High
Prostate Cancer 34 50.00 Quite Low
B-cell Lymphoma 1 48.68 Quite Low
Nasopharynx Cancer 3 47.64 Quite Low
Epstein-barr Virus 29 45.28 Quite Low
Lymphatic System Cancer 9 43.84 Quite Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be determined whether a single mechanism plays a dominant role or BAD-dependent stimulation of proliferation is mediated via several mechanisms simultaneously, and whether BAD localization to a specific organelle (e.g. mitochondria, ER, nuclear envelope) is important.
Localization (localization) of BAD
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.66 Pain Relevance 0.06
The accession numbers for the peptides were: human BimL (AAC39594), human Puma (AAK39542), mouse Bmf (AAK38747), human Bad (NP_004313), human Bik (NP_001188), human Hrk (NP_003797), human Bid (NP_001187), human Noxa (NP_066950), human Bax (NP_620119), human Bak (NP_001179), mouse Mule (UniProt Accession code Q7TMY8; residues 1969–1994; PGGTTQEVGQLLQDMGDDVYQQYRSL) and mmBeclin (UniProt Accession code O88597, residue 103–128; DGGTMENLSRRLKVTGDLFDIMSGQT).


Localization (human) of Bad
2) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0 Pain Relevance 0.03

General Comments

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