INT275180

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.79
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 99.90 Very High Very High Very High
agonist 4 99.82 Very High Very High Very High
Morphine 60 91.16 High High
withdrawal 3 57.00 Quite High
antagonist 9 38.28 Quite Low
Inflammation 8 15.48 Low Low
Opioid 18 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 118 99.68 Very High Very High Very High
Prostate Cancer 102 99.56 Very High Very High Very High
Cancer 77 96.40 Very High Very High Very High
Infection 34 92.56 High High
Targeted Disruption 20 80.96 Quite High
Breast Cancer 3 73.88 Quite High
Mycobacterial Infection 44 50.00 Quite Low
Hypoxia 3 49.96 Quite Low
Death 4 39.04 Quite Low
INFLAMMATION 10 15.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combination of proliferative and apoptotic properties prompts prostate cancer cells to be “addicted” to increased levels of phosphorylated BAD.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of BAD associated with prostate cancer and apoptosis
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.33 Pain Relevance 0
If so, high levels of phosphorylated BAD could be used to identify patients who will benefit from therapy with such inhibitors.
Positive_regulation (levels) of Phosphorylation (phosphorylated) of BAD
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.46 Pain Relevance 0
This combination of proliferative and apoptotic properties creates conditions for prostate cancer cells “addiction” to increased levels of phosphorylated BAD.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of BAD associated with addiction, prostate cancer and apoptosis
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.20 Pain Relevance 0.08
It has been demonstrated that TLR9 agonist CpG-DNA induces phosphorylation of Bad, a pro-apoptotic member of the Bcl-2 family, at Ser112 and Ser136 through activation of Akt [27].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of Bad associated with agonist and apoptosis
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.79 Pain Relevance 0.69

General Comments

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