INT275232

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DUOX2, ROS1) cell differentiation (ROS1) cell proliferation (ROS1)
oxidoreductase activity (DUOX2)
DUOX2 (Homo sapiens)
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 11.08 Low Low
addiction 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 99.52 Very High Very High Very High
Toxicity 4 64.12 Quite High
Small Cell Lung Cancer 14 41.76 Quite Low
Cancer 40 36.08 Quite Low
Skin Cancer 8 5.00 Very Low Very Low Very Low
Reprotox - General 1 6 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 4 5.00 Very Low Very Low Very Low
Solid Tumor 4 5.00 Very Low Very Low Very Low
Nephrotoxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytotoxicity of oxoplatin was evidenced by DNA damage-inducible genes, generation of ROS by dual oxidase 2 (DUOX2), and cell death was most likely linked to increased expression of caspase 3 (Table 1).
dual oxidase 2 Positive_regulation (generation) of ROS associated with death
1) Confidence 0.10 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.16 Pain Relevance 0
Cytotoxicity of oxoplatin was evidenced by DNA damage-inducible genes, generation of ROS by dual oxidase 2 (DUOX2), and cell death was most likely linked to increased expression of caspase 3 (Table 1).
DUOX2 Positive_regulation (generation) of ROS associated with death
2) Confidence 0.03 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.16 Pain Relevance 0

General Comments

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