INT275232

Context Info Confidence 0.10 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.33 Pain Relevance 0

plasma membrane (DUOX2, ROS1) cell differentiation (ROS1) cell proliferation (ROS1) oxidoreductase activity (DUOX2)

DUOX2 (Homo sapiens) ROS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 4 11.08 addiction 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Death 10 99.52 Toxicity 4 64.12 Small Cell Lung Cancer 14 41.76 Cancer 40 36.08 Skin Cancer 8 5.00 Reprotox - General 1 6 5.00 Colon Cancer 6 5.00 Bacterial Respiratory Disease 4 5.00 Solid Tumor 4 5.00 Nephrotoxicity 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cytotoxicity of oxoplatin was evidenced by DNA damage-inducible genes, generation of ROS by dual oxidase 2 (DUOX2), and cell death was most likely linked to increased expression of caspase 3 (Table 1).

dual oxidase 2 Positive_regulation (generation) of ROS associated with death

1) Confidence 0.10 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.16 Pain Relevance 0

Cytotoxicity of oxoplatin was evidenced by DNA damage-inducible genes, generation of ROS by dual oxidase 2 (DUOX2), and cell death was most likely linked to increased expression of caspase 3 (Table 1).

DUOX2 Positive_regulation (generation) of ROS associated with death

2) Confidence 0.03 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.16 Pain Relevance 0

General Comments

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