INT275245

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (HIST2H2BE) nucleus (HIST2H2BE) DNA binding (HIST2H2BE)
Anatomy Link Frequency
B-cells 1
HIST2H2BE (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 45.56 Quite Low
pruritus 1 36.24 Quite Low
abdominal pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 13 98.60 Very High Very High Very High
Thrombocytopenia 9 93.88 High High
Anorexia 4 92.76 High High
Bartter Syndrome 1 91.80 High High
Vomiting 29 91.04 High High
Diarrhoea 6 90.40 High High
Lymphatic System Cancer 15 84.48 Quite High
Myelodysplastic Syndromes 15 78.44 Quite High
Precursor Cell Lymphoblastic Leukemia-lymphoma 3 78.08 Quite High
Myeloid Leukemia 18 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 55 genes upregulated more than fourfold in oxoplatin-treated H526 cells only three genes, namely, HIST2H2BE, PNUTL2, and AKR1C3, were in common with those genes upregulated in cisplatin-treated cells (the 27 genes exhibiting the strongest increases in expression triggered by oxoplatin are shown in Table 1).
Positive_regulation (upregulated) of HIST2H2BE
1) Confidence 0.15 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.17 Pain Relevance 0
H3 and H2B acetylation increase was significant in B-cells and blasts.
Positive_regulation (increase) of H2B in B-cells
2) Confidence 0.11 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.76 Pain Relevance 0

General Comments

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