INT275265

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.41
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 6
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 427 100.00 Very High Very High Very High
dorsal root ganglion 350 99.84 Very High Very High Very High
Neuropeptide 7 96.64 Very High Very High Very High
antagonist 35 94.48 High High
Inflammation 147 84.72 Quite High
Hyperalgesia 56 81.92 Quite High
Pain 42 81.64 Quite High
IPN 21 59.36 Quite High
analgesia 14 54.76 Quite High
rheumatoid arthritis 7 53.64 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 357 99.84 Very High Very High Very High
Hypersensitivity 21 95.60 Very High Very High Very High
Increased Venous Pressure Under Development 14 93.92 High High
Targeted Disruption 70 90.56 High High
INFLAMMATION 161 84.72 Quite High
Nervous System Injury 28 83.68 Quite High
Hyperalgesia 70 81.92 Quite High
Pain 42 81.64 Quite High
Inflammatory Pain 21 59.36 Quite High
Rheumatoid Arthritis 7 53.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiment, blocking ROS production also abolished TNFR1 increases.
Negative_regulation (abolished) of Positive_regulation (increases) of TNFR1
1) Confidence 0.56 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.39 Pain Relevance 0.36
The present study shows PBN blocks TNFR1 increases induced by capsaicin.
Negative_regulation (blocks) of Positive_regulation (increases) of TNFR1 associated with qutenza
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.61 Pain Relevance 0.55
Capsazepine blocks capsaicin induced TNFR1 increase in DRG neurons from wild type mice
Negative_regulation (blocks) of Positive_regulation (increase) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
3) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.60 Pain Relevance 1.13
PBN blocks capsaicin induced TNFR1 increase in DRG neurons of wild type mice
Negative_regulation (blocks) of Positive_regulation (increase) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
4) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.67 Pain Relevance 1.21
PBN blocks capsaicin induced TNFR1 increases
Negative_regulation (blocks) of Positive_regulation (increases) of TNFR1 associated with qutenza
5) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.87 Pain Relevance 0.74
M, 10 min) blocked TNFR1 increases induced by capsaicin (1 ?
Negative_regulation (blocked) of Positive_regulation (increases) of TNFR1 associated with qutenza
6) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.60 Pain Relevance 1.20
Pretreatment with PBN (2 mM, 90 min) of cultured DRG neurons from wild type mice blocked the TNFR1 increases induced by capsaicin (1 ?
Negative_regulation (blocked) of Positive_regulation (increases) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
7) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.67 Pain Relevance 1.15

General Comments

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