INT27529

Context Info Confidence 0.47 First Reported 1989 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 23 Total Number 24 Disease Relevance 1.16 Pain Relevance 20.18

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency projection neurons 1 adrenal medulla 1 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 364 100.00 agonist 107 100.00 Opioid 75 100.00 antagonist 47 100.00 narcan 3 100.00 opiate 6 99.92 medulla 10 99.88 Enkephalin 24 99.84 Kinase C 62 99.76 withdrawal 6 99.72

Disease Link Frequency Relevance Heat Targeted Disruption 3 95.52 Neuroblastoma 6 90.56 Pain 19 89.72 Drug Dependence 1 88.40 Glioma 2 75.00 Bordatella Infection 1 74.64 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 32 5.00 Urological Neuroanatomy 18 5.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 15 5.00 Nociception 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As described for most of GPCRs, opioid receptor desensitization involves their phosphorylation by kinases and their uncoupling from G-proteins realized by arrestins.

Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor

1) Confidence 0.47 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16750901 Disease Relevance 0.15 Pain Relevance 0.79

Also, the role of G-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed.

Phosphorylation (phosphorylation) of opioid-receptor associated with opioid

2) Confidence 0.21 Published 2009 Journal Neurosci Biobehav Rev Section Abstract Doc Link 19747597 Disease Relevance 0 Pain Relevance 0.99

Here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments.

Phosphorylation (phosphorylation) of opioid-receptor associated with agonist and opioid

3) Confidence 0.21 Published 2009 Journal Neurosci Biobehav Rev Section Abstract Doc Link 19747597 Disease Relevance 0 Pain Relevance 1.04

Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.

Phosphorylation (phosphorylation) of delta-opioid receptor associated with tolerance, opioid receptor, antinociceptive and morphine

4) Confidence 0.20 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.53

Receptor trafficking induced by mu-opioid-receptor phosphorylation.

Phosphorylation (phosphorylation) of opioid-receptor associated with opioid

5) Confidence 0.19 Published 2009 Journal Neurosci Biobehav Rev Section Title Doc Link 19747597 Disease Relevance 0 Pain Relevance 1.06

Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons.

Phosphorylation (phosphorylation) of delta-opioid receptor in projection neurons associated with agonist, enkephalin, projection neuron and opioid receptor

6) Confidence 0.15 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.70

Previous studies have shown that once phosphoryled, the opioid receptor binds to ?

Phosphorylation (phosphoryled) of opioid receptor associated with opioid receptor

7) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.58

Finally, highly purified recombinant betaARK1 proved active to phosphorylate enriched delta-opioid receptor preparations in an opioid agonist-dependent manner.

Phosphorylation (phosphorylate) of delta-opioid receptor associated with mu agonist and opioid receptor

8) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9413931 Disease Relevance 0.29 Pain Relevance 0.34

Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

9) Confidence 0.05 Published 1997 Journal Cell. Signal. Section Title Doc Link 9376223 Disease Relevance 0.07 Pain Relevance 0.54

Recent studies have shown that during its biosynthesis in bovine adrenal medulla, the opioid precursor proenkephalin A, may be both N-glycosylated and phosphorylated.

Phosphorylation (phosphorylated) of opioid precursor in adrenal medulla associated with medulla and opioid

10) Confidence 0.04 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2623194 Disease Relevance 0 Pain Relevance 0.57

Besides, the opioid receptor desensitization involves phosphorylation of receptors and subsequent binds to beta-arrestin.

Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor

11) Confidence 0.03 Published 2004 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 15346705 Disease Relevance 0.32 Pain Relevance 2.06

Withdrawal caused by an opioid receptor antagonist - naloxone - attenuated phosphorylation of ERK1/2.

Phosphorylation (phosphorylation) of opioid receptor associated with antagonist, narcan, opioid receptor and withdrawal

12) Confidence 0.03 Published 2008 Journal FEBS J. Section Abstract Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.93

These results represent the identification of the GRK phosphorylation site on an opioid receptor for the first time and demonstrate that GRK is the prominent kinase responsible for agonist-induced opioid receptor phosphorylation in vivo.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

13) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.51

In this study, the mouse delta-opioid receptor (delta OR) was used in a model system to investigate the role of opioid receptor phosphorylation in receptor desensitization.

Spec (investigate) Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor

14) Confidence 0.02 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651349 Disease Relevance 0 Pain Relevance 0.79

Taken together, we have demonstrated that agonist-induced opioid receptor phosphorylation occurs exclusively at two phosphate acceptor sites (T358 and S363) of GRK2 at the DOR carboxyl terminus.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

15) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.70

The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment.

Phosphorylation (phosphorylation) of opioid receptor associated with opioid receptor and opioid

16) Confidence 0.02 Published 2005 Journal Neurosignals Section Title Doc Link 16772732 Disease Relevance 0.09 Pain Relevance 0.91

Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.

Phosphorylation (phosphorylation) of opioid receptor associated with kinase c and opioid receptor

17) Confidence 0.02 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11085981 Disease Relevance 0 Pain Relevance 0.77

These results represent the identification of the GRK phosphorylation site on an opioid receptor for the first time and demonstrate that GRK is the prominent kinase responsible for agonist-induced opioid receptor phosphorylation in vivo.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

18) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.61

Our previous research suggested that agonist-induced delta-opioid receptor (DOR) phosphorylation occurs at the receptor carboxyl terminal domain.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

19) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.83

Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.

Phosphorylation (phosphorylation) of opioid receptor associated with agonist and opioid receptor

20) Confidence 0.02 Published 2000 Journal Mol. Pharmacol. Section Title Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.95

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