INT27534

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.23
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Gba)
Anatomy Link Frequency
liver 2
spleen 2
lymph nodes 1
bone marrow 1
Gba (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 16 86.64 High High
Central nervous system 8 82.24 Quite High
Inflammation 14 63.04 Quite High
Arthritis 4 43.20 Quite Low
cva 3 25.00 Low Low
imagery 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 48 99.88 Very High Very High Very High
Lysosome Storage Disease 6 99.52 Very High Very High Very High
Lysosomal Storage Diseases 4 99.38 Very High Very High Very High
Disease 30 95.36 Very High Very High Very High
Anaemia 5 92.56 High High
Thrombocytopenia 5 91.92 High High
Lipidosis 1 90.08 High High
Farber Lipogranulomatosis 41 89.24 High High
Spontaneous Fractures 3 89.04 High High
Intellectual Impairment 1 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Type 1 Gaucher disease, the most common lysosomal storage disorder, results from deficiency of glucocerebrosidase causing pathologic accumulation of glucocerebroside.
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease and lysosome storage disease
1) Confidence 0.57 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 16996765 Disease Relevance 0.85 Pain Relevance 0
Gaucher s disease is an autosomal recessive lysosomal storage disease characterized by the specific deficiency of glucocerebrosidase that leads to accumulation of insoluble glucocerebroside in the reticuloendothelial system, particularly the bone marrow, liver, spleen and lymph nodes.
Negative_regulation (deficiency) of glucocerebrosidase in lymph nodes associated with lysosomal storage diseases and gauchers disease
2) Confidence 0.57 Published 1996 Journal Eur J Nucl Med Section Abstract Doc Link 8612670 Disease Relevance 0.36 Pain Relevance 0
The metabolic defect in Gaucher disease is a deficiency of the lysosomal enzyme glucocerebrosidase.
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease
3) Confidence 0.22 Published 1996 Journal J Intraven Nurs Section Abstract Doc Link 8852167 Disease Relevance 0.73 Pain Relevance 0.13
Because of lack of the specific b-glucosidase, glucocerebrosidase, there is increased deposition of glucocerebrosides in the reticulo-endothelial system, mostly in the spleen, liver, and bone-marrow.
Negative_regulation (lack) of glucocerebrosidase in liver
4) Confidence 0.21 Published 1989 Journal Z Rheumatol Section Abstract Doc Link 2623978 Disease Relevance 0.61 Pain Relevance 0.07
Gaucher s disease is an autosomal recessive lysosomal storage disease characterized by the specific deficiency of glucocerebrosidase that leads to accumulation of insoluble glucocerebroside in the reticuloendothelial system, particularly the bone marrow, liver, spleen and lymph nodes.
Negative_regulation (deficiency) of glucocerebrosidase in spleen associated with lysosomal storage diseases and gauchers disease
5) Confidence 0.19 Published 1996 Journal Eur J Nucl Med Section Abstract Doc Link 8612670 Disease Relevance 0.36 Pain Relevance 0
Gaucher s disease is an autosomal recessive lysosomal storage disease characterized by the specific deficiency of glucocerebrosidase that leads to accumulation of insoluble glucocerebroside in the reticuloendothelial system, particularly the bone marrow, liver, spleen and lymph nodes.
Negative_regulation (deficiency) of glucocerebrosidase in liver associated with lysosomal storage diseases and gauchers disease
6) Confidence 0.19 Published 1996 Journal Eur J Nucl Med Section Abstract Doc Link 8612670 Disease Relevance 0.36 Pain Relevance 0
Gaucher s disease is an autosomal recessive lysosomal storage disease characterized by the specific deficiency of glucocerebrosidase that leads to accumulation of insoluble glucocerebroside in the reticuloendothelial system, particularly the bone marrow, liver, spleen and lymph nodes.
Negative_regulation (deficiency) of glucocerebrosidase in bone marrow associated with lysosomal storage diseases and gauchers disease
7) Confidence 0.19 Published 1996 Journal Eur J Nucl Med Section Abstract Doc Link 8612670 Disease Relevance 0.36 Pain Relevance 0
Because of lack of the specific b-glucosidase, glucocerebrosidase, there is increased deposition of glucocerebrosides in the reticulo-endothelial system, mostly in the spleen, liver, and bone-marrow.
Negative_regulation (lack) of glucocerebrosidase in spleen
8) Confidence 0.07 Published 1989 Journal Z Rheumatol Section Abstract Doc Link 2623978 Disease Relevance 0.61 Pain Relevance 0.07
Gaucher disease is a lysosomal storage disorder caused by a recessively inherited deficiency of glucocerebrosidase activity, which causes an accumulation of sphingolipid glucosylceramide in cells of the reticulo-endothelial systems [1].
Negative_regulation (deficiency) of glucocerebrosidase associated with gauchers disease and lysosome storage disease
9) Confidence 0.01 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1164415 Disease Relevance 0.60 Pain Relevance 0
One patient is classified as type 7, showing a combined deficiency of glucocerebrosidase, galactocerebrosidase and ceramidase due to a mutation of prosaposin, the precursor protein for two sphingolipid activator proteins [9].


Negative_regulation (deficiency) of glucocerebrosidase
10) Confidence 0.01 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1920510 Disease Relevance 1.40 Pain Relevance 0.13

General Comments

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