INT27536

Context Info Confidence 0.52 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.41 Pain Relevance 1.13

Anatomy Link Frequency CPA 1 sympathetic nervous system 1 Caf (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 4 100.00 cytokine 12 99.98 Locus ceruleus 348 98.44 antagonist 26 89.72 adenocard 5 88.92 Clonidine 38 82.24 cocaine 6 62.24 Dopamine 11 57.20 noradrenaline 57 43.68 Codeine 4 25.00

Disease Link Frequency Relevance Heat Death 2 99.96 Immunization 20 90.80 Mycobacterial Infection 48 63.20 Pressure Volume 2 Under Development 1 38.64 Miosis 8 32.64 Ehlers-danlos Syndrome 2 27.60 Sleep Disorders 15 27.04 Idiopathic Hypersomnolence 1 17.36 Apnoea 1 12.24 Demyelinating Disease 1 9.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, combined administration of 4 drugs and MEPH + CAF + CPA at the doses equivalent to those contained in 40ml/kg of BRON produced death of 1 or 2 mice out of 10-14.

Gene_expression (produced) of CAF in CPA associated with death

1) Confidence 0.52 Published 1989 Journal Arukoru Kenkyuto Yakubutsu Ison Section Abstract Doc Link 2624570 Disease Relevance 0.10 Pain Relevance 0

In the case of CRS model, A1(1) (1%, 1 cm) were used to obtain three linear equation functions and this linear equation system was resolved by the Cramer's rule for the prediction of PAR, CAF and ASP in samples.

Gene_expression (prediction) of CAF associated with paracetamol

2) Confidence 0.36 Published 2005 Journal Chem. Pharm. Bull. Section Abstract Doc Link 16079516 Disease Relevance 0 Pain Relevance 0.30

cytokine production of Ag:CAF01:Bioneedle as compared to Ag:CAF01 (Figure 1B).

Gene_expression (production) of CAF01 associated with cytokine

3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993957 Disease Relevance 0.15 Pain Relevance 0.05

cytokine production of Ag:CAF01:Bioneedle as compared to Ag:CAF01 (Figure 1B).

Gene_expression (production) of CAF01 associated with cytokine

4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993957 Disease Relevance 0.15 Pain Relevance 0.05

Administration of caffeine also produces increases in heart rate [194], blood pressure [194, 315, 464] and temperature [229], consistent with activation of the sympathetic nervous system.

Gene_expression (produces) of caffeine in sympathetic nervous system

5) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0 Pain Relevance 0.73

General Comments

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