INT275366

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.64
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
neuronal 4
neurons 2
brain 2
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Electroencephalography 52 93.28 High High
antagonist 24 83.52 Quite High
agonist 19 80.92 Quite High
Neurotransmitter 9 76.60 Quite High
Calcium channel 3 70.36 Quite High
GABAergic 29 65.24 Quite High
anesthesia 4 62.04 Quite High
Pyramidal cell 10 57.00 Quite High
Hippocampus 17 55.28 Quite High
gABA 24 51.48 Quite High
Disease Link Frequency Relevance Heat
Death 48 99.90 Very High Very High Very High
Apoptosis 100 99.60 Very High Very High Very High
Convulsion 252 98.80 Very High Very High Very High
Epilepsy 77 96.80 Very High Very High Very High
Injury 4 71.16 Quite High
Status Epilepticus 4 70.64 Quite High
Hypotension 1 40.08 Quite Low
Urological Neuroanatomy 15 29.36 Quite Low
Fetal Alcohol Syndrome 16 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact evidence suggests that presynaptic GABAB receptors are mainly comprised of GABAB1a/GABAB2 subunits (Billinton et al., 1999; Towers et al., 2000), so pharmacological differences would be unexpected.
Negative_regulation (comprised) of Gene_expression (presynaptic) of GABAB
1) Confidence 0.22 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.30
The results showed that GABAB1R expression at mRNA level in hippocampal neurons was decreased significantly in PTZ-induced seizure model as compare to control group (Figure 5a).
Negative_regulation (decreased) of Gene_expression (expression) of GABAB1R in neurons associated with convulsion
2) Confidence 0.15 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.76 Pain Relevance 0.06
This study for the first time indicate that PTZ-induced seizures triggered activation of caspases-3 to induce widespread apoptotic neuronal death and decreased GABAB1R expression in hippocampal neurons, providing a possible mechanistic link between maternal epilepsy induced neurodegeneration alteration of GABAB1R and PKA expression level during prenatal brain development.
Negative_regulation (decreased) of Gene_expression (expression) of GABAB1R in neuronal associated with epilepsy, convulsion, apoptosis and death
3) Confidence 0.15 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.00 Pain Relevance 0.17
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Negative_regulation (decrease) of Gene_expression (expression) of GABAB1R in brain associated with convulsion
4) Confidence 0.15 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.70 Pain Relevance 0.03
The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABAB1R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group.
Negative_regulation (decreased) of Gene_expression (expression) of GABAB1R in neuronal associated with convulsion
5) Confidence 0.15 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.19 Pain Relevance 0.29

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