INT275367

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 2.15
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
brain 6
spinal cord 2
dorsal horn 2
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 79 100.00 Very High Very High Very High
Calcitonin gene-related peptide 32 100.00 Very High Very High Very High
Spinal cord 126 99.60 Very High Very High Very High
Dorsal horn 5 99.28 Very High Very High Very High
dexamethasone 43 99.20 Very High Very High Very High
substance P 29 98.22 Very High Very High Very High
GABAergic 124 97.76 Very High Very High Very High
Lasting pain 9 95.44 Very High Very High Very High
Pain 20 90.92 High High
Neuronal excitability 9 90.08 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 108 99.92 Very High Very High Very High
Convulsion 63 99.86 Very High Very High Very High
Pain 30 95.44 Very High Very High Very High
Epilepsy 26 94.76 High High
Death 12 90.60 High High
Apoptosis 25 90.00 High High
Status Epilepticus 1 70.64 Quite High
Targeted Disruption 7 45.64 Quite Low
Nociception 25 5.00 Very Low Very Low Very Low
Stress 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABAB receptors are present postsynaptically on SPNs and high concentrations of the GABAB agonist, baclofen (10–100??
Positive_regulation (concentrations) of Gene_expression (present) of GABAB associated with agonist
1) Confidence 0.26 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.26 Pain Relevance 0.59
Expression of all GABAB subunits was observed in both the spinal cord and IML samples (n?
Positive_regulation (observed) of Gene_expression (Expression) of GABAB in spinal cord associated with urological neuroanatomy and spinal cord
2) Confidence 0.26 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.55 Pain Relevance 0.19
There are developmental changes in GABAB receptor subunits since GABAB1(a) is predominant during embryonic period and at birth whilst GABAB1(b) expression increases during the first postnatal month in the brain (Fritschy et al., 1994).
Positive_regulation (increases) of Gene_expression (expression) of GABAB receptor in brain
3) Confidence 0.26 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.10
GABAB receptors are present postsynaptically on SPNs and high concentrations of the GABAB agonist, baclofen (10–100??
Positive_regulation (concentrations) of Gene_expression (agonist) of GABAB associated with agonist
4) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.25 Pain Relevance 0.55
Here we show that a low concentration of the GABAB agonist baclofen (1??
Positive_regulation (concentration) of Gene_expression (agonist) of GABAB associated with agonist
5) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Abstract Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.14
 ; GABAB2 reverse 5?
Positive_regulation (reverse) of Gene_expression (reverse) of GABAB2
6) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.08 Pain Relevance 0.07
There are developmental changes in GABAB receptor subunits since GABAB1(a) is predominant during embryonic period and at birth whilst GABAB1(b) expression increases during the first postnatal month in the brain (Fritschy et al., 1994).
Positive_regulation (increases) of Gene_expression (expression) of GABAB1 in brain
7) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.07
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Positive_regulation (triggers) of Gene_expression (expression) of GABAB1R in brain associated with convulsion
8) Confidence 0.17 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.71 Pain Relevance 0.03
In fact, the behavioural differences observed between CORT and DEX treatment at 28 days were paralleled by distinct patterns in CGRP, SP and GABAB2 expression in the superficial dorsal horn: while in CORT-treated animals the expression of both CGRP and GABAB2 was restored to control levels, DEX treatment resulted in a decreased expression of SP and CGRP and sustained increase in GABAB2.
Positive_regulation (restored) of Gene_expression (expression) of GABAB2 in dorsal horn associated with dorsal horn, dexamethasone, substance p and calcitonin gene-related peptide
9) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.31 Pain Relevance 1.10

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