INT275368

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.21
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cyct) transport (Cyct) mitochondrion (Cyct)
Anatomy Link Frequency
neuronal 2
neurons 1
respiratory 1
Cyct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Electroencephalography 39 95.24 Very High Very High Very High
anesthesia 4 64.00 Quite High
Hippocampus 12 5.52 Low Low
Kinase C 21 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
GABAergic 9 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 138 99.80 Very High Very High Very High
Convulsion 189 99.36 Very High Very High Very High
Death 50 79.60 Quite High
Epilepsy 57 78.48 Quite High
Stress 41 75.00 Quite High
Parkinson's Disease 8 64.60 Quite High
Congenital Anomalies 1 52.88 Quite High
Injury 10 24.04 Low Low
Hepatotoxicity 14 9.08 Low Low
Body Weight 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABAB1R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group.
Gene_expression (expression) of cytochrome-c in neuronal associated with convulsion
1) Confidence 0.65 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.18 Pain Relevance 0.30
Figure 2(a) illustrated that exposure of cultured hippocampal neurons to ethanol, PTZ, ethanol plus PTZ and KA caused significant increased expression of cytochrome-c in PTZ-induced seizure as compare to non PTZ treated group, suggesting that release of cytochrome-c into the cytoplasm induces the formation of apoptosome.
Gene_expression (expression) of cytochrome-c in neurons associated with convulsion
2) Confidence 0.65 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.43 Pain Relevance 0.07
The merge image (yellow) indicated the release of cytochrome-c and caspase-3 expression into cytosol as a result of PTZ and ethanol exposure in the hippocampal neuronal cells culture (Figure 2b).


Gene_expression (expression) of cytochrome-c in neuronal
3) Confidence 0.65 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.21 Pain Relevance 0
Our results show that treatment of Caco-2/15 cells with FE/ASC (0.2 mM/2 mM) (1) increased malondialdehyde levels assessed by HPLC; (2) reduced ATP production noted by luminescence assay; (3) provoked dysregulation of mitochondrial calcium homeostasis as evidenced by confocal fluorescence microscopy; (4) upregulated the protein expression of cytochrome C and apoptotic inducing factor, indicating exaggerated apoptosis; (5) affected mitochondrial respiratory chain complexes I, II, III and IV; (6) elicited mtDNA lesions as illustrated by the raised levels of 8-OHdG; (7) lowered DNA glycosylase, one of the first lines of defense against 8-OHdG mutagenicity; and (8) altered the gene expression and protein mass of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2) without any effects on RNA Polymerase.
Gene_expression (expression) of cytochrome C in respiratory associated with apoptosis
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2910735 Disease Relevance 0.51 Pain Relevance 0
To confirm As-induced mitochondria-dependent apoptosis, we determined the mitochondrial membrane potential, intracellular ATP level as well as expressions of Bcl-2 family and BH-3 only proteins, cytochrome c, caspase 3, caspase 9, Apaf1 and PARP in arsenic-induced hepatic pathophysiology and observed that As significantly up-regulated pro-apoptotic (Bad, Bax, Bim) and down-regulated anti-apoptotic (Bcl-2, Bcl-xL) proteins, reduced mitochondrial membrane potential and intracellular ATP level, increased cytochrome c release and protein level of Apaf-1 in the cytosol.
Gene_expression (expressions) of cytochrome c associated with apoptosis
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.87 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox