INT275370

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cyct) transport (Cyct) mitochondrion (Cyct)
Anatomy Link Frequency
neuronal 2
neurons 2
Cyct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Electroencephalography 26 95.64 Very High Very High Very High
anesthesia 2 64.40 Quite High
gABA 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
GABAergic 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 126 99.36 Very High Very High Very High
Apoptosis 50 80.88 Quite High
Death 24 80.00 Quite High
Epilepsy 38 78.88 Quite High
Fetal Alcohol Syndrome 8 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Absence Epilepsy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2(a) illustrated that exposure of cultured hippocampal neurons to ethanol, PTZ, ethanol plus PTZ and KA caused significant increased expression of cytochrome-c in PTZ-induced seizure as compare to non PTZ treated group, suggesting that release of cytochrome-c into the cytoplasm induces the formation of apoptosome.
Positive_regulation (increased) of Gene_expression (expression) of cytochrome-c in neurons associated with convulsion
1) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.44 Pain Relevance 0.07
The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABAB1R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group.
Positive_regulation (increased) of Gene_expression (expression) of cytochrome-c in neuronal associated with convulsion
2) Confidence 0.49 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.18 Pain Relevance 0.30

General Comments

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