INT275381

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 8.15
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Htatsf1) nucleus (Htatsf1)
Anatomy Link Frequency
sensory neurons 1
Spinal 1
nerves 1
neurons 1
peripheral nerve 1
Htatsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 7 99.96 Very High Very High Very High
Pain 119 99.92 Very High Very High Very High
chemokine 21 99.68 Very High Very High Very High
Analgesic 70 96.84 Very High Very High Very High
Neuropathic pain 140 96.60 Very High Very High Very High
intrathecal 7 95.84 Very High Very High Very High
Central nervous system 35 91.72 High High
unmyelinated 28 88.28 High High
Endep 56 77.76 Quite High
Morphine 49 76.56 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 763 100.00 Very High Very High Very High
Gliosis 21 99.98 Very High Very High Very High
Pain 84 99.92 Very High Very High Very High
Hypersensitivity 147 99.52 Very High Very High Very High
Neuropathic Pain 238 99.24 Very High Very High Very High
Toxicity 7 98.36 Very High Very High Very High
Infection 28 97.94 Very High Very High Very High
Apoptosis 63 87.04 High High
Neuropathy 70 82.48 Quite High
Injury 70 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that at times of peak behavioural sensitivity, nerves treated with HIV-1 gp120 are not associated with a significant axonal regenerative process.
HIV-1 Binding (treated) of in nerves associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.76 Pain Relevance 0.11
Spinal gliosis following perineural HIV-1 gp120
HIV-1 Binding (following) of in Spinal associated with acquired immune deficiency syndrome or hiv infection and gliosis
2) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.73 Pain Relevance 0.10
HIV-1 gp120 associated mechanical hypersensitivity is selectively responsive to clinically effective analgesic drugs
HIV-1 Binding (associated) of associated with analgesic, hypersensitivity and acquired immune deficiency syndrome or hiv infection
3) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.86 Pain Relevance 0.68
HIV-1 gp120 binds to the chemokine receptors CXCR4 and CCR5, the natural ligands of which (SDF-1a and RANTES) can induce behavioural correlates of pain in rats (Oh et al., 2001).
HIV-1 Binding (binds) of associated with pain, chemokine and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.42 Pain Relevance 0.45
Accordingly, peripheral administration of gp120 is associated with the development of pain-like behaviour in rats (Herzberg and Sagen, 2001) suggesting the possibility that HIV-1 gp120 interactions with the peripheral nerve may be a causative factor in the generation of peripheral neuropathic pain in humans.
HIV-1 Binding (interactions) of in peripheral nerve associated with pain, acquired immune deficiency syndrome or hiv infection and neuropathic pain
5) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.25 Pain Relevance 0.76
In the peripheral nervous system, HIV-1 gp120 can influence the activity (Oh et al., 2001) and survival (Keswani et al., 2003) of sensory neurons and has recently been shown to interact directly with axons in vitro leading to toxicity (Melli et al., 2006).
HIV-1 Binding (interact) of in sensory neurons associated with toxicity, peripheral nervous system and acquired immune deficiency syndrome or hiv infection
6) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.41 Pain Relevance 0.63
Direct infection of the nervous system by HIV is thought to be unlikely (Michaels et al., 1988; Lipton, 1998) instead, HIV-1 appears to interact indirectly with neurons via binding of the external envelope protein, gp120, to the chemokine receptors CXCR4 and/or CCR5.
HIV-1 Binding (interact) of in neurons associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
7) Confidence 0.03 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.74 Pain Relevance 0.49

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