INT275383

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 5.72
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Htatsf1) nucleus (Htatsf1)
Anatomy Link Frequency
nerve 2
neuronal 1
Spinal 1
neurons 1
microglia 1
Htatsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 56 99.68 Very High Very High Very High
c fibre 40 98.52 Very High Very High Very High
Pain 136 94.52 High High
Analgesic 80 85.76 High High
Sciatic nerve 144 82.12 Quite High
Peripheral nerve injury 24 81.44 Quite High
Thermal hyperalgesia 8 80.88 Quite High
Spinal cord 48 80.72 Quite High
agonist 40 75.60 Quite High
Cannabinoid receptor 24 75.28 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 872 100.00 Very High Very High Very High
Gliosis 24 100.00 Very High Very High Very High
Injury 80 98.16 Very High Very High Very High
Neuropathic Pain 272 96.16 Very High Very High Very High
Pain 96 94.52 High High
Hypersensitivity 168 91.80 High High
Apoptosis 72 87.20 High High
Hyperalgesia 8 80.88 Quite High
Nervous System Injury 64 80.56 Quite High
Demyelinating Disease 16 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, co-localisation with NF-200 indicated that 85% of ATF3 expressing neurons ipsilateral to HIV-1 gp120 at day 14 were small diameter C-fibre neurons (1252 of 1483 ATF3-IR cells were NF-200 negative) (Fig. 7A, a).
Gene_expression (expressing) of HIV-1 in neurons associated with c fibre and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.06 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.75 Pain Relevance 0.19
Furthermore, at day 14, there was a significant spread of CD-68-IR macrophages into the proximal region of the HIV-1 gp120 treated nerve which was not apparent in the sham or in the distal portion of the nerve in any treatment group (Fig. 6A).
Gene_expression (proximal region) of HIV-1 in nerve associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.06 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.68 Pain Relevance 0.07
Spinal gliosis following perineural HIV-1 gp120
Gene_expression (gliosis) of HIV-1 in Spinal associated with acquired immune deficiency syndrome or hiv infection and gliosis
3) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.73 Pain Relevance 0.10
Although of a smaller magnitude than seen in nerve lesion models, these changes suggest that HIV-1 gp120 in the nerve can produce changes usually associated with actual nerve trauma and may further reflect gp120 induced axonal injury.
Gene_expression (produce) of HIV-1 in nerve associated with injury and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.14 Pain Relevance 0.28
Alterations in non-neuronal cells in the DRG following perineural HIV-1 gp120
Gene_expression (following) of HIV-1 in neuronal associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.53 Pain Relevance 0.16
At day 14, microglia in the dorsal horn ipsilateral to perineural HIV-1 gp120 scored 2.1 ± 0.2 versus 0.9 ± 0.3 contralaterally, indicating that there was a significant qualitative, morphological change.
Gene_expression (perineural) of HIV-1 in microglia associated with acquired immune deficiency syndrome or hiv infection and dorsal horn
6) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.42 Pain Relevance 0.19
LM and EM analysis reveals that overt axonal damage is not a consequence of perineural HIV-1 gp120 treatment
Gene_expression (treatment) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.79 Pain Relevance 0.32
By day 45 post HIV-1 gp120 application, CD68-IR had returned to basal levels (data not shown).


Gene_expression (application) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.05 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.69 Pain Relevance 0.13

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