INT275390

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.26
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) aging (Ccr5) nucleolus (Htatsf1)
nucleus (Htatsf1) plasma membrane (Ccr5) cell-cell signaling (Ccr5)
Anatomy Link Frequency
neurons 1
Ccr5 (Rattus norvegicus)
Htatsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 6 100.00 Very High Very High Very High
Pain 34 99.92 Very High Very High Very High
Central nervous system 10 95.12 Very High Very High Very High
unmyelinated 8 88.28 High High
Neuropathic pain 40 84.12 Quite High
intrathecal 2 76.88 Quite High
Peripheral nervous system 2 69.84 Quite High
Stimulus evoked pain 2 61.08 Quite High
Sciatic nerve 36 5.00 Very Low Very Low Very Low
Analgesic 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 218 100.00 Very High Very High Very High
Pain 24 99.92 Very High Very High Very High
Neuropathic Pain 68 99.24 Very High Very High Very High
Infection 8 97.94 Very High Very High Very High
Apoptosis 18 96.80 Very High Very High Very High
Neuropathy 20 82.48 Quite High
Gliosis 6 73.88 Quite High
Injury 20 70.64 Quite High
Disease 6 70.08 Quite High
Congenital Anomalies 4 58.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HIV-1 gp120 binds to the chemokine receptors CXCR4 and CCR5, the natural ligands of which (SDF-1a and RANTES) can induce behavioural correlates of pain in rats (Oh et al., 2001).
CCR5 Binding (binds) of HIV-1 associated with pain, chemokine and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.43 Pain Relevance 0.45
Direct infection of the nervous system by HIV is thought to be unlikely (Michaels et al., 1988; Lipton, 1998) instead, HIV-1 appears to interact indirectly with neurons via binding of the external envelope protein, gp120, to the chemokine receptors CXCR4 and/or CCR5.
CCR5 Binding (binding) of HIV-1 in neurons associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.83 Pain Relevance 0.52

General Comments

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