INT275398

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.05
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) nucleolus (Htatsf1) nucleus (Htatsf1)
plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
neurons 2
peripheral nerve 2
ITIH4 (Homo sapiens)
Htatsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 12 99.64 Very High Very High Very High
Pain 68 98.34 Very High Very High Very High
Neuropathic pain 80 96.60 Very High Very High Very High
calcitonin gene related peptide 24 91.80 High High
Neuropeptide 8 91.56 High High
Central nervous system 20 91.44 High High
unmyelinated 16 88.28 High High
Peripheral nervous system 4 84.08 Quite High
intrathecal 4 80.00 Quite High
Stimulus evoked pain 4 61.08 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 436 100.00 Very High Very High Very High
Pain 48 98.34 Very High Very High Very High
Infection 16 97.94 Very High Very High Very High
Neuropathic Pain 136 97.04 Very High Very High Very High
Apoptosis 36 93.12 High High
Toxicity 4 92.16 High High
Injury 40 87.08 High High
Neuropathy 40 82.48 Quite High
Disease 12 70.08 Quite High
Congenital Anomalies 8 58.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct infection of the nervous system by HIV is thought to be unlikely (Michaels et al., 1988; Lipton, 1998) instead, HIV-1 appears to interact indirectly with neurons via binding of the external envelope protein, gp120, to the chemokine receptors CXCR4 and/or CCR5.
gp120 Binding (binding) of HIV-1 in neurons associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.02 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.76 Pain Relevance 0.51
By day 14, there was no overall change in the expression of TRPV1 in neurons in the DRG ipsilateral to perineural HIV-1 gp120 versus sham treatment or DRG contralateral to perineural HIV-1 gp120 (Table 3, Fig. 7B, a).
gp120 Binding (perineural) of HIV-1 in neurons associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.78 Pain Relevance 0.21
Accordingly, peripheral administration of gp120 is associated with the development of pain-like behaviour in rats (Herzberg and Sagen, 2001) suggesting the possibility that HIV-1 gp120 interactions with the peripheral nerve may be a causative factor in the generation of peripheral neuropathic pain in humans.
gp120 Binding (interactions) of HIV-1 in peripheral nerve associated with pain, acquired immune deficiency syndrome or hiv infection and neuropathic pain
3) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.25 Pain Relevance 0.76
Accordingly, peripheral administration of gp120 is associated with the development of pain-like behaviour in rats (Herzberg and Sagen, 2001) suggesting the possibility that HIV-1 gp120 interactions with the peripheral nerve may be a causative factor in the generation of peripheral neuropathic pain in humans.
gp120 Binding (interactions) of HIV-1 in peripheral nerve associated with pain, acquired immune deficiency syndrome or hiv infection and neuropathic pain
4) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.25 Pain Relevance 0.76

General Comments

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