INT275403

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.45
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4, GOLPH3) plasma membrane (Cxcr4, GOLPH3) mitochondrion (GOLPH3)
Golgi apparatus (GOLPH3) cytoplasm (GOLPH3) signal transducer activity (Cxcr4)
Cxcr4 (Rattus norvegicus)
GOLPH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 3 99.48 Very High Very High Very High
Neuropathic pain 20 96.04 Very High Very High Very High
Pain 17 95.76 Very High Very High Very High
peripheral neuropathy 2 85.20 High High
Central nervous system 5 78.24 Quite High
Sciatic nerve 18 72.56 Quite High
Gabapentin 7 46.72 Quite Low
Morphine 7 45.76 Quite Low
Cannabinoid 4 44.40 Quite Low
Endep 8 41.28 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 100.00 Very High Very High Very High
Neurological Disease 1 100.00 Very High Very High Very High
Neuropathic Pain 34 96.48 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 5 96.20 Very High Very High Very High
Hypersensitivity 21 66.16 Quite High
Anxiety Disorder 3 56.00 Quite High
Gliosis 3 25.00 Low Low
Pain 12 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Neuropathy 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HIV coat protein, glycoprotein 120 (gp120), implicated in the pathogenesis of neurological disorders associated with HIV, is capable of initiating neurotoxic cascades via an interaction with the CXCR4 and/or CCR5 chemokine receptors, which may underlie the pathogenesis of HIV-associated peripheral neuropathic pain.
CXCR4 Binding (interaction) of HIV coat protein associated with chemokine, neurological disease, acquired immune deficiency syndrome or hiv infection and neuropathic pain
1) Confidence 0.00 Published 2007 Journal Pain Section Abstract Doc Link PMC2706950 Disease Relevance 1.45 Pain Relevance 0.52

General Comments

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