INT275409

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.87
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, Cxcr4) endosome (Cxcr4) extracellular region (ITIH4)
cytoplasmic membrane-bounded vesicle (Cxcr4) signal transducer activity (Cxcr4) cytoplasm (ITIH4)
ITIH4 (Homo sapiens)
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 6 100.00 Very High Very High Very High
Pain 34 99.68 Very High Very High Very High
Neuropathic pain 40 96.04 Very High Very High Very High
Central nervous system 10 91.48 High High
peripheral neuropathy 4 85.20 High High
Sciatic nerve 36 72.56 Quite High
Gabapentin 14 46.72 Quite Low
Morphine 14 45.76 Quite Low
Cannabinoid 8 44.40 Quite Low
Endep 16 41.28 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 218 100.00 Very High Very High Very High
Neurological Disease 2 100.00 Very High Very High Very High
Pain 24 99.68 Very High Very High Very High
Neuropathic Pain 68 99.00 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 10 94.76 High High
Infection 8 91.88 High High
Gliosis 6 73.64 Quite High
Injury 20 69.92 Quite High
Hypersensitivity 42 66.16 Quite High
Apoptosis 18 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HIV coat protein, glycoprotein 120 (gp120), implicated in the pathogenesis of neurological disorders associated with HIV, is capable of initiating neurotoxic cascades via an interaction with the CXCR4 and/or CCR5 chemokine receptors, which may underlie the pathogenesis of HIV-associated peripheral neuropathic pain.
gp120 Binding (interaction) of CXCR4 associated with chemokine, neurological disease, acquired immune deficiency syndrome or hiv infection and neuropathic pain
1) Confidence 0.09 Published 2007 Journal Pain Section Abstract Doc Link PMC2706950 Disease Relevance 1.44 Pain Relevance 0.52
HIV-1 gp120 binds to the chemokine receptors CXCR4 and CCR5, the natural ligands of which (SDF-1a and RANTES) can induce behavioural correlates of pain in rats (Oh et al., 2001).
gp120 Binding (binds) of CXCR4 associated with pain, chemokine and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.09 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.42 Pain Relevance 0.45

General Comments

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