INT275436

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.74
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TYROBP) plasma membrane (TYROBP) intracellular (TYROBP)
Anatomy Link Frequency
NK cells 10
B lymphocytes 2
TYROBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Sicca syndrome 6 51.12 Quite High
Inflammation 36 30.76 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
Rheumatism 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 204 99.38 Very High Very High Very High
Acute Myeloid Leukemia 6 98.12 Very High Very High Very High
Plasmacytoma 12 78.40 Quite High
Autoimmune Disease 6 54.56 Quite High
Syndrome 18 51.12 Quite High
Disease 36 34.60 Quite Low
INFLAMMATION 30 30.76 Quite Low
Dementia 6 6.16 Low Low
Encephalitis 6 5.64 Low Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was previously described by western-blot analysis a down-regulation of DAP12 expression in NK cells from SLE patients.
Negative_regulation (regulation) of Gene_expression (expression) of DAP12 in NK cells associated with systemic lupus erythematosus
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.71 Pain Relevance 0
In addition, this study shows that the functional deficiency of NK cell cytotoxicity in SLE patients is not related to an abnormal expression of the NK cell receptors or DAP12 protein, as it has been previously shown with NCRs in acute myelogenous leukaemia [27].


Negative_regulation (abnormal) of Gene_expression (expression) of DAP12 protein in NK cell associated with acute myeloid leukemia and systemic lupus erythematosus
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.54 Pain Relevance 0
Since a decreased expression of DAP12 has been suggested in NK cells of systemic lupus erythematosus patients, we have further investigated the NK cell receptor repertoire and leukocyte expression of DAP12 in these patients and no major changes were detectable when compared to controls.



Negative_regulation (decreased) of Gene_expression (expression) of DAP12 in NK cells associated with systemic lupus erythematosus
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2707004 Disease Relevance 0.17 Pain Relevance 0
It was previously described by western-blot analysis a down-regulation of DAP12 expression in NK cells from SLE patients.
Negative_regulation (down) of Gene_expression (expression) of DAP12 in NK cells associated with systemic lupus erythematosus
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.71 Pain Relevance 0
Contrary to our results, Toyabe et al. have reported a decreased expression of DAP12 in NK cells from SLE patients by using western blot analysis with a rabbit anti-human DAP12 antibody [21].
Negative_regulation (decreased) of Gene_expression (expression) of DAP12 in NK cells associated with systemic lupus erythematosus
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.53 Pain Relevance 0.03
DAP12 expression was barely detected in CD8+ T lymphocytes, CD4+ T lymphocytes, CD19+ B lymphocytes, ??
Negative_regulation (detected) of Gene_expression (expression) of DAP12 in B lymphocytes
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.07 Pain Relevance 0

General Comments

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