INT275462

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN)
extracellular matrix organization (MMP9) DNA binding (JUN) protein complex (MMP9)
JUN (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 60.08 Quite High
Inflammation 3 59.36 Quite High
Arthritis 4 57.68 Quite High
metalloproteinase 62 50.00 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 3 88.04 High High
Arthralgia 1 60.56 Quite High
INFLAMMATION 3 59.36 Quite High
Arthritis 4 57.68 Quite High
Disease 5 7.52 Low Low
Cancer 10 6.16 Low Low
Toxicity 5 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low
Wrinkles 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection studies carried out with MMP-9 and AP-1 reporter constructs suggested that the observed reduction in MMP-9 expression was due to down-regulation of MMP-9 transcription which mediated via inhibition of AP-1.
Negative_regulation (inhibition) of AP-1 Positive_regulation (due) of Gene_expression (expression) of MMP-9
1) Confidence 0.04 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.27 Pain Relevance 0.12

General Comments

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