INT27551

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 13
Speculated 3
Reported most in Body
Documents 45
Total Number 49
Disease Relevance 42.87
Pain Relevance 9.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1) response to stress (SERPINH1)
Anatomy Link Frequency
erythrocyte 6
margin 3
internal 2
urine 2
B19 1
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 587 100.00 Very High Very High Very High
Inflammation 377 100.00 Very High Very High Very High
Arthritis 278 100.00 Very High Very High Very High
cytokine 139 100.00 Very High Very High Very High
Inflammatory response 23 98.74 Very High Very High Very High
psoriasis 36 98.28 Very High Very High Very High
abatacept 121 97.36 Very High Very High Very High
metalloproteinase 19 96.68 Very High Very High Very High
cINOD 15 95.84 Very High Very High Very High
Pain 48 93.92 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 593 100.00 Very High Very High Very High
Disease 412 100.00 Very High Very High Very High
Dermal Scarring 240 100.00 Very High Very High Very High
Arthritis 115 100.00 Very High Very High Very High
Pre-term Labor 113 100.00 Very High Very High Very High
Experimental Arthritis 26 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 16 100.00 Very High Very High Very High
Cv Unclassified Under Development 5 100.00 Very High Very High Very High
Neurodegenerative Disease 4 100.00 Very High Very High Very High
Seronegative Spondarthritis 146 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of SERPINH1, which showed a 5.7-fold upregulation in keloid margin in this study (P = .003), has been suggested to promote excessive collagen deposition in keloids.33 LGALS1 is a type of lectin that has been implicated in cell-cell and cell-matrix interactions and has been suggested to be involved in tumor progression, at least partly, through the induction of T-cell apoptosis.34 IGFBP7 shows a 2.8-fold upregulation in keloid margins (P = .022).
Gene_expression (overexpression) of SERPINH1 in margin associated with dermal scarring, cancer, apoptosis and keloid scars
1) Confidence 0.62 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.06 Pain Relevance 0
Two CpG islands were examined for HSP47 methylation, one in the 5?
Spec (examined) Gene_expression (methylation) of HSP47
2) Confidence 0.59 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.15 Pain Relevance 0
Two CpG islands were examined for HSP47 methylation, one in the 5?
Spec (examined) Gene_expression (examined) of HSP47
3) Confidence 0.59 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.15 Pain Relevance 0
In addition, expression of HSP47 correlated with that of collagen I and IV.
Gene_expression (expression) of HSP47
4) Confidence 0.53 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.28 Pain Relevance 0
Previously, expression of HSP47 was reported to be upregulated after treatment with 5-aza-dC in the neuroblastoma cell line NB2-W-S and promoter region methylation was detected in neuroblastoma cell lines and 4/7 primary neuroblastoma tumours analysed (Yang et al. 2004).
Gene_expression (expression) of HSP47 associated with neuroblastoma and cancer
5) Confidence 0.53 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.06 Pain Relevance 0
Rheumatoid factor and human leukocyte antigen B-27 were negative.
Neg (negative) Gene_expression (negative) of Rheumatoid factor in leukocyte
6) Confidence 0.51 Published 2009 Journal Mod Rheumatol Section Abstract Doc Link 19083078 Disease Relevance 0.99 Pain Relevance 0.46
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of SERPINH1 in internal associated with dermal scarring
7) Confidence 0.48 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Her erythrocyte sedimentation rate was markedly elevated; tests for rheumatoid factor were negative.
Neg (negative) Gene_expression (negative) of rheumatoid factor in erythrocyte
8) Confidence 0.43 Published 1989 Journal J. Rheumatol. Section Abstract Doc Link 2625694 Disease Relevance 0.45 Pain Relevance 0.14
Finally, our gene set contains markers for a range of different cell differentiation fates, including embryonic development (AMD1, SERPINH1), vasculogenesis (S100A4), hematopoesis (B2M, IGFBP6, IKZF5), neurogenesis (BASP1, SERPINH1), and even osteoclastogenesis (CTSB, CTSD, CTSK); it is possible that these genes are downregulated in response to our osteogenic stimulus.
Gene_expression (neurogenesis) of SERPINH1 associated with neurodegenerative disease
9) Confidence 0.43 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2527292 Disease Relevance 0.33 Pain Relevance 0
However, although the data in Figure 4 shows that a similar proportion of the PTL with intact membranes and PPROM groups had both bacteria and chorioamnionitis 25% of cases in the PPROM group had chorioamnionitis but no bacteria, whilst approx 25% of the PTL group had bacteria but no chorioamnionitis.
Gene_expression (proportion) of PPROM associated with chorioamnionitis and pre-term labor
10) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.94 Pain Relevance 0.03
In indicated preterm delivery there was a complete absence of histological chorioamnionitis, in contrast PPROM and PTL groups had significantly higher incidence of histological chorioamnionitis (88% and 68% respectively).
Gene_expression (groups) of PPROM associated with chorioamnionitis, premature birth and pre-term labor
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 1.55 Pain Relevance 0.13
However there were a number of cases in the PPROM and PTL groups that were positive for either bacteria or histological chorioamnionitis but not for both.
Gene_expression (groups) of PPROM associated with chorioamnionitis and pre-term labor
12) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 1.47 Pain Relevance 0.11
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of SERPINH1 in internal associated with dermal scarring
13) Confidence 0.21 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
In multivariate logistical regression analysis with neonatal sepsis as a dependent variable and a panel of clinical (amniocentesis-to-delivery interval, clinical chorioamnionitis, GA at delivery, and PPROM) or AF biochemical characteristics as independent variables, the MR score, but not the WBC count, was the only variable with significant predictive value (MR 3┬ľ4: p = 0.03, WBC count: p = 0.48)

Performance of the MR Score and Other Rapid Markers in Identification of Intra-amniotic Inflammation and Infection

Gene_expression (count) of PPROM associated with inflammation, chorioamnionitis, infection and sepsis
14) Confidence 0.17 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.85 Pain Relevance 0.12
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of SERPINH1 in margin associated with dermal scarring
15) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Only in the case of PPROM, higher concentrations are detectable in CVF.
Gene_expression (detectable) of PPROM
16) Confidence 0.14 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.30 Pain Relevance 0
Only the AmniSure┬« ROM test for the diagnosis of PPROM, based upon the detection of placental ?
Gene_expression (diagnosis) of PPROM
17) Confidence 0.14 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0 Pain Relevance 0
Erythrocyte sedimentation rate, C-reactive protein and haemoglobin were normal and rheumatoid factor, antinuclear antibodies and antibodies to Borrelia were negative.
Neg (negative) Gene_expression (negative) of rheumatoid factor in Erythrocyte
18) Confidence 0.14 Published 2008 Journal The Open Rheumatology Journal Section Body Doc Link PMC2577945 Disease Relevance 0.39 Pain Relevance 0.29
Rheumatoid factor was negative in all cases, and antinuclear antibodies (ANA) were positive in two.
Neg (negative) Gene_expression (negative) of Rheumatoid factor
19) Confidence 0.12 Published 2004 Journal Rheumatol. Int. Section Abstract Doc Link 12750942 Disease Relevance 0.81 Pain Relevance 0.07
He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19.
Neg (negative) Gene_expression (negative) of rheumatoid factor in B19 associated with chlamydia infection and infection
20) Confidence 0.11 Published 2005 Journal Mod Rheumatol Section Abstract Doc Link 17029078 Disease Relevance 1.02 Pain Relevance 0.24

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