INT275510

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
macrophage 2
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 2 98.12 Very High Very High Very High
chemokine 15 94.48 High High
cytokine 47 94.36 High High
antagonist 19 92.44 High High
rheumatoid arthritis 6 90.36 High High
Inflammatory mediators 9 89.20 High High
Inflammation 137 88.40 High High
isoflurane 6 69.00 Quite High
ketamine 2 66.76 Quite High
anesthesia 3 47.92 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 2 98.12 Very High Very High Very High
Rheumatoid Arthritis 6 90.36 High High
INFLAMMATION 140 88.80 High High
Pulmonary Disease 107 87.36 High High
Targeted Disruption 3 84.20 Quite High
Viral Bronchiolitis 18 74.20 Quite High
Pneumonia 25 72.72 Quite High
Exsanguination 2 71.76 Quite High
Apoptosis 5 34.92 Quite Low
Respiratory Syncytial Virus 42 28.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we observed a significant azithromycin-dependent decrease in G-CSF and decreased concentrations, albeit not statistically significant, of CCL2/JE, CCL3/MIP-1?
Negative_regulation (decreased) of CCL2 Neg (not) Binding (concentrations) of
1) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.64 Pain Relevance 0.33
Multiplex bead immunoassay (Lincoplex) was performed according to the manufacturer's protocol on the Luminex 100 platform to measure concentrations of KC/CXCL1, MCP-1/CCL2, MIP-1?
Negative_regulation (measure) of CCL2 Binding (concentrations) of
2) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.19
Binding of CCL2 to its CCR2 receptor can also be blocked by RS-504393, which is able to inhibit macrophage infiltration and activation (Kitagawa et al 2004).
Negative_regulation (blocked) of CCL2 Binding (Binding) of in macrophage
3) Confidence 0.22 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.75 Pain Relevance 0.41

General Comments

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