INT27554

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Context Info
Confidence 0.52
First Reported 1988
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 6.76
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
capillary 1
smooth muscle cells 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 48 94.32 High High
Dismenorea 1 72.92 Quite High
fibrosis 5 64.44 Quite High
Pain 3 60.80 Quite High
Spinal cord 6 60.72 Quite High
anesthesia 5 53.96 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Williams-beuren Syndrome 3 99.08 Very High Very High Very High
Hypertension 12 99.04 Very High Very High Very High
Diabetes Mellitus 98 98.82 Very High Very High Very High
Edema 2 97.80 Very High Very High Very High
Hypertrophy 6 97.78 Very High Very High Very High
Syndrome 73 96.72 Very High Very High Very High
Congenital Anomalies 6 94.56 High High
INFLAMMATION 54 94.32 High High
Hyperglycemia 1 93.92 High High
Diabetes Complications 7 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collagen density was decreased by treatment (-42%, p < 0.05), whereas elastin density was not affected by treatment.
Neg (not) Regulation (affected) of elastin
1) Confidence 0.52 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8328370 Disease Relevance 0.17 Pain Relevance 0.05
Modification of aortic thickness was due to hypertrophy of smooth muscle cells with parallel modifications of absolute amount of collagen, whereas absolute amount of elastin did not change in this early phase of renovascular hypertension in young rats.
Neg (not) Regulation (change) of elastin in smooth muscle cells associated with hypertrophy and hypertension
2) Confidence 0.44 Published 1988 Journal Circ. Res. Section Abstract Doc Link 3383377 Disease Relevance 0.71 Pain Relevance 0
Analysis of focus genes in networks, functional analysis, and canonical pathway analysis reinforced our previous findings related to the presence of up-regulated genes involved in tissue remodeling, such as lysyl oxidase, tropoelastin, TGF-?
Regulation (regulated) of tropoelastin
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688838 Disease Relevance 0.94 Pain Relevance 0.21
One must: 1) reinforce the vaso-constrictive effect and the parietal tone, 2) limit collagen and elastin alteration, 3) reinforce capillary permeability and decrease the interstitial edema, 4) normalize the haemorheological constants, 5) restore the balance hemostasis-fibrinolysis.
Regulation (alteration) of elastin in capillary associated with edema
4) Confidence 0.08 Published 1989 Journal Phlebologie Section Abstract Doc Link 2626464 Disease Relevance 0.38 Pain Relevance 0.07
The diagnosis of Williams syndrome can be confirmed or excluded by FISH studies targeting the elastin (ELN) gene at 7q11.2, just as appropriate laboratory studies can detect deletion 22q13.


Regulation (targeting) of elastin associated with williams-beuren syndrome
5) Confidence 0.02 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2427010 Disease Relevance 2.75 Pain Relevance 0.06
In diabetic patients, extra-cellular and long lived proteins, such as elastin, laminin, collagen are the major targets of free radicals.
Regulation (targets) of elastin associated with diabetes mellitus
6) Confidence 0.02 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275761 Disease Relevance 1.82 Pain Relevance 0

General Comments

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