INT27555

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Context Info
Confidence 0.14
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.38
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 1
lymphocyte 1
medial 1
internal 1
skin 1
Ec (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 10 99.92 Very High Very High Very High
Glutamate 8 99.80 Very High Very High Very High
imagery 6 95.84 Very High Very High Very High
withdrawal 2 94.72 High High
lidocaine 8 93.68 High High
Inflammation 124 93.60 High High
Inflammatory marker 6 92.96 High High
cva 4 92.52 High High
Angina 4 89.08 High High
rheumatoid arthritis 160 87.84 High High
Disease Link Frequency Relevance Heat
Varicose Veins 334 100.00 Very High Very High Very High
Hypoxia 2 99.84 Very High Very High Very High
INFLAMMATION 136 99.56 Very High Very High Very High
Hemorrhage 152 99.48 Very High Very High Very High
Adhesions 18 99.02 Very High Very High Very High
Pressure And Volume Under Development 76 98.68 Very High Very High Very High
Injury 12 96.76 Very High Very High Very High
Rupture 18 95.76 Very High Very High Very High
Targeted Disruption 188 93.44 High High
Cv General 3 Under Development 8 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that the inflamed setting of the skin graft activated graft EC to become better APC or that dead EC were cross presented by professional APC.
Positive_regulation (activated) of EC in skin
1) Confidence 0.14 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.20 Pain Relevance 0.09
We also tested the effect of EC activation on lymphocyte recognition by denuding endothelium from femoral arteries by wire injury in TIE2-lacZ mice immunized against ?
Positive_regulation (activation) of EC in lymphocyte associated with injury
2) Confidence 0.10 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.15 Pain Relevance 0
-gal and there were no changes in the intimal, medial or overall vessel areas (Jun Yu and William Sessa, personal communication), suggesting that activated EC in large vessels are not able to activate specific T cells in vivo.


Positive_regulation (activated) of EC in medial
3) Confidence 0.09 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.35 Pain Relevance 0
APC of EcV has been reported to be effective in stopping bleeding and eradicating ileocolonic anastomotic varices in a 65-year-old male patient [71].
Positive_regulation (effective) of EcV associated with varicose veins and hemorrhage
4) Confidence 0.05 Published 2008 Journal Hepatol Int Section Body Doc Link PMC2716887 Disease Relevance 1.37 Pain Relevance 0
For example, DC adhesion and transmigration are markedly increased after exposing EC to hypoxia, oxidized LDL or TNF.
Positive_regulation (exposing) of EC associated with hypoxia and adhesions
5) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 1.39 Pain Relevance 0.46
Most of the available data about EcV are obtained from case reports or short series of cases.EcV are being recognized more frequently nowadays because of the continuous advances in the endoscopic and imaging techniques.Ectopic variceal bleeding is reported in patients with internal haemorrhage, hypovolaemic shock, occult gastrointestinal bleeding, anaemia or bleeding from the gut of obscure origin, especially in patients with PHT, following abdominal surgical procedures, in cases with extrahepatic venous obstruction or thrombosis, or anomalies of the portal venous system.It is difficult to recommend general guidelines for the management of EcV and each case should be dealt with depending on the site and severity of bleeding and according to available expertise and facilities.Patients with EcV bleeding must be considered difficult, should be managed in specialized canters, and have to be approached with a multidisciplinary team involving intensivists, gastroenterologists, surgeons and interventional radiologists.



Positive_regulation (series) of EcV in internal associated with pressure and volume under development, varicose veins, shock, hemorrhage, thrombosis related under development, edema, anaemia, cva and imagery
6) Confidence 0.05 Published 2008 Journal Hepatol Int Section Body Doc Link PMC2716887 Disease Relevance 1.81 Pain Relevance 0.09
EC activation promotes vascular permeability, oedema and leukocyte recruitment.
Positive_regulation (activation) of EC in leukocyte associated with pressure and volume under development
7) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 1.57 Pain Relevance 0.41
E/ChrR complex (PDB ID 2Z2S) or the Ec ?
Positive_regulation (/) of Ec
8) Confidence 0.03 Published 2010 Journal Journal of Molecular Biology Section Body Doc Link PMC2877774 Disease Relevance 0.09 Pain Relevance 0
The results indicated that the stimulations of EC and MSG to SNT and TNT enhanced respiratory activity obviously.
Positive_regulation (stimulations) of EC in respiratory associated with glutamate
9) Confidence 0.02 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2626687 Disease Relevance 0 Pain Relevance 0.56
Stimulation of EC and MSG to ONT caused much less enhancement of respiration.
Positive_regulation (Stimulation) of EC associated with glutamate
10) Confidence 0.02 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2626687 Disease Relevance 0 Pain Relevance 0.56
For EC, CO, and NO this increase was also seen for lag 4 (data for CO and NO not shown).
Positive_regulation (increase) of EC
11) Confidence 0.01 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.09 Pain Relevance 0.05
Increased levels of fibrinogen were observed for an increase in one interquartile range of UFP, PM10, EC, OC, CO, and NO revealing the strongest effect for lag 3.
Positive_regulation (increase) of EC
12) Confidence 0.01 Published 2009 Journal Part Fibre Toxicol Section Abstract Doc Link PMC2762952 Disease Relevance 0.35 Pain Relevance 0.08

General Comments

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