INT275553

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Ccr5, Ccl3) cytoplasm (Ccr5, Ccl3) endosome (Ccr5)
intracellular (Ccl3) signal transducer activity (Ccr5) cytosol (Ccl3)
Anatomy Link Frequency
macrophage 2
Ccr5 (Mus musculus)
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 19 93.32 High High
chemokine 10 90.88 High High
Arthritis 2 75.92 Quite High
rheumatoid arthritis 6 68.16 Quite High
Inflammation 49 48.48 Quite Low
cytokine 18 5.00 Very Low Very Low Very Low
corticosteroid 13 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 107 97.88 Very High Very High Very High
Arthritis 2 75.92 Quite High
Rheumatoid Arthritis 6 68.16 Quite High
Targeted Disruption 3 62.00 Quite High
Dyspnea 1 50.32 Quite High
INFLAMMATION 47 48.48 Quite Low
Apoptosis 5 12.72 Low Low
Respiratory Syncytial Virus 1 5.84 Low Low
Disease 16 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, these drugs are unable to significantly reduce macrophage chemoattraction because they inhibit only CCL3, but not CCL4 binding to CCR5, thus probably not being of particular interest for COPD treatment.


Negative_regulation (inhibit) of CCR5 Binding (binding) of CCL3 in macrophage associated with pulmonary disease
1) Confidence 0.05 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.73 Pain Relevance 0.26

General Comments

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