INT275555

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.02 Pain Relevance 0.30

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)

Ltb4r1 (Mus musculus) COPD (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 19 100.00 Inflammation 49 93.20 fibrosis 3 71.60 Inflammatory mediators 1 54.16 trigger zone 1 12.52 cytokine 18 5.00 corticosteroid 13 5.00 chemokine 10 5.00 rheumatoid arthritis 6 5.00 metalloproteinase 5 5.00

Disease Link Frequency Relevance Heat Pulmonary Disease 107 100.00 INFLAMMATION 47 93.20 Asthma 10 75.12 Cystic Fibrosis 1 72.16 Disease 16 60.52 Vomiting 1 8.64 Adhesions 7 5.52 Stress 11 5.00 Nicotine Addiction 10 5.00 Rheumatoid Arthritis 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several selective BLT1 antagonists are currently under investigation for their potential therapeutic use in COPD.

BLT1 Binding (use) of COPD associated with pulmonary disease and antagonist

1) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.02 Pain Relevance 0.30

General Comments

This test has worked.