INT275575

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.81
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (FOLR1) extracellular region (FOLR1) plasma membrane (FOLR1)
Anatomy Link Frequency
T cells 9
FOLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 10 94.48 High High
cytokine 190 84.08 Quite High
Inflammation 121 72.44 Quite High
endometriosis 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 99.64 Very High Very High Very High
Neuritis 10 94.48 High High
Colitis 10 93.52 High High
Cancer 107 93.36 High High
Ovarian Cancer 34 92.96 High High
Graft Vs Host Disease 20 88.16 High High
INFLAMMATION 120 72.44 Quite High
Apoptosis 16 72.04 Quite High
Aneuploidy 3 70.00 Quite High
Malignant Neoplastic Disease 20 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The folate receptor alpha (FR?)
Gene_expression (alpha) of folate receptor
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2707611 Disease Relevance 0.50 Pain Relevance 0
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Gene_expression (expression) of FOLR associated with endometrial cancer
2) Confidence 0.52 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.22 Pain Relevance 0
Custom designed P&P sets were validated by serially diluting cDNA isolated from cells expressing the target and verifying the slope, and by sequencing the amplicon.
Gene_expression (expressing) of cells
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.06
While examining the requirements to optimize generation of human CD4+IL-9+ T cells, we found that IL-1?
Gene_expression (generation) of cells in T cells
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.06 Pain Relevance 0.03
Our analysis which includes a successful effort to optimize IL-9 expression or frequency of CD4+IL-9+ T cells and their molecular phenotype reveals both similarities and distinctions between human and murine IL-9+ T cells.
Gene_expression (expression) of cells in T cells
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.03
In-so-far, these CD4+IL-9+ T cells generated from memory CD4+ T cells are different from mouse CD4+IL-9+ T cells generated from naïve CD4+ T cells in the following aspects: 1) human CD4+IL-9+ T cells express GATA3 and RORC; 2) some human CD4+IL-9+ T cells express FOXP3 and; 3) human CD4+IL-9+ T cells do not express IL-10.
Gene_expression (express) of cells in T cells
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.16 Pain Relevance 0.16
On the other hand, this study shows certain similarities between mouse and human systems, where like in mouse, human CD4+IL-9+ T cells do not express Tbet, IFN?
Neg (not) Gene_expression (express) of cells in T cells
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.07
T cells to express IL-9.
Gene_expression (express) of cells in T cells
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.04
in combination induced IL-9 expression in both naïve and memory CD4+ T cells, but higher percentage of memory CD4+ T cells expressed IL-9.
Gene_expression (expression) of cells in T cells
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.03
With more than one subset of CD4+ T cells producing IL-9, existence of “Th9” cells as a new subset is debatable.
Gene_expression (producing) of cells in T cells
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.20 Pain Relevance 0.14
In-so-far, these CD4+IL-9+ T cells generated from memory CD4+ T cells are different from mouse CD4+IL-9+ T cells generated from naïve CD4+ T cells in the following aspects: 1) human CD4+IL-9+ T cells express GATA3 and RORC; 2) some human CD4+IL-9+ T cells express FOXP3 and; 3) human CD4+IL-9+ T cells do not express IL-10.
Gene_expression (express) of cells in T cells
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.11 Pain Relevance 0.11
RII-transfected fibroblasts, induces naïve or memory CD4+ T cells to produce IL-9 [14].
Gene_expression (produce) of cells in T cells
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.36 Pain Relevance 0.14

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