INT275587

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4B) signal transduction (PDE4B) nucleus (PDE4B)
cytoplasm (PDE4B)
PDE4B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 99.44 Very High Very High Very High
agonist 35 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 99.44 Very High Very High Very High
Vomiting 5 96.40 Very High Very High Very High
Pulmonary Disease 131 95.00 High High
Stress 2 52.00 Quite High
Bronchitis 1 39.04 Quite Low
Bacterial Infection 3 30.84 Quite Low
Pneumonia 2 10.48 Low Low
Disease 11 5.00 Very Low Very Low Very Low
Asthma 7 5.00 Very Low Very Low Very Low
Nicotine Addiction 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of PDE4B is mainly responsible for the anti-inflammatory effects of PDE4 inhibitors, whereas inhibition of PDE4D causes nausea which is one of the main adverse effects of these drugs (Lipworth 2005).
Regulation (responsible) of Negative_regulation (Inhibition) of PDE4B associated with inflammation and vomiting
1) Confidence 0.08 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.89 Pain Relevance 0.10

General Comments

This test has worked.

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