INT275642

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.08
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
colon 1
small intestine 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 98.70 Very High Very High Very High
Crohn's disease 160 63.80 Quite High
fibrosis 2 52.20 Quite High
ischemia 4 50.40 Quite High
Nicotine 14 36.32 Quite Low
Inflammation 22 5.00 Very Low Very Low Very Low
cINOD 14 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Colon Cancer 45 94.40 High High
Cancer 107 76.48 Quite High
Cardiovascular Disease 1 69.36 Quite High
Nicotine Addiction 194 64.72 Quite High
Congenital Anomalies 8 64.64 Quite High
Disease 190 63.80 Quite High
Fibrosis 2 52.20 Quite High
Cv Unclassified Under Development 4 50.40 Quite High
Increased Venous Pressure Under Development 2 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin/Tcf signaling efficiently although a common mechanism by which flavonoids inhibit Tcf activity remains to be established.
Negative_regulation (inhibit) of Tcf
1) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.39 Pain Relevance 0
Thus, we examined the effect of PLD isoform-selective inhibitor on TCF activity.
Spec (examined) Negative_regulation (inhibitor) of TCF
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.09 Pain Relevance 0
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Negative_regulation (repression) of TCF in colon associated with antagonist and repression
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.80 Pain Relevance 0.22
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Negative_regulation (repression) of TCF in small intestine associated with antagonist and repression
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.80 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox