INT275724

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 14
Disease Relevance 7.49
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 3
skeletal muscle 3
cortex 2
spinal 1
third ventricle 1
xn (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 14 70.28 Quite High
Potency 28 22.48 Low Low
vagus nerve 14 5.00 Very Low Very Low Very Low
Somatostatin 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 350 97.48 Very High Very High Very High
Diabetes Mellitus 252 96.44 Very High Very High Very High
Parkinson's Disease 14 91.20 High High
Aging 28 87.72 High High
Obesity 14 85.60 High High
Neurodegenerative Disease 14 81.52 Quite High
Body Weight 14 71.96 Quite High
Apoptosis 210 67.36 Quite High
Insulin Resistance 70 55.04 Quite High
Drug Induced Neurotoxicity 14 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothalamic delivery of the STAT-3 inhibitor showed no effect on its own, yet completely abolished HN-induced suppression of HGP and peripheral glucose uptake.


Negative_regulation (abolished) of HN
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
We conclude that the decline in HN with age could play a role in the pathogenesis of age-related diseases including AD and T2DM.
Negative_regulation (decline) of HN associated with diabetes mellitus and disease
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.55 Pain Relevance 0
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in hypothalamus
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.73 Pain Relevance 0
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in hypothalamus
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.63 Pain Relevance 0
The link between the decrease in circulating levels of HN as well as levels in hypothalamus and skeletal muscle with age, in parallel with the increase in age- associated diseases such as AD and T2DM is extremely intriguing and warrants further investigation.
Negative_regulation (decrease) of HN in hypothalamus associated with diabetes mellitus and disease
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 1.02 Pain Relevance 0
To test the role of STAT-3 activation in the mediation of HN actions, we co-infused HN along with a STAT-3 inhibitor [28] ICV and showed that the effects of HN are completely attenuated in the presence of the STAT-3 inhibitor (Fig. 3C–3F).
Negative_regulation (attenuated) of HN
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
HN levels decreased with age in both mice (Fig. 8A, P<0.05) and humans (Fig. 8B, P<0.05).
Negative_regulation (decreased) of HN
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.22 Pain Relevance 0
Likewise, we show that co-infusion of a STAT-3 inhibitor with HN into the third ventricle completely attenuates the ability of HN to modulate peripheral insulin action.
Negative_regulation (inhibitor) of HN in third ventricle
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.35 Pain Relevance 0
A primed-continuous ICV infusion of HN, F6AHN (total dose of 20 ug), dimerization deficient (DD) HN, STAT-3 inhibitor (75 pmol) , or artificial cerebro-spinal fluid (aCSF) was initiated at t?
Negative_regulation (inhibitor) of HN in spinal
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.26 Pain Relevance 0.07
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in skeletal muscle
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.73 Pain Relevance 0
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in cortex
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.63 Pain Relevance 0
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in skeletal muscle
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.63 Pain Relevance 0
The link between the decrease in circulating levels of HN as well as levels in hypothalamus and skeletal muscle with age, in parallel with the increase in age- associated diseases such as AD and T2DM is extremely intriguing and warrants further investigation.
Negative_regulation (decrease) of HN in skeletal muscle associated with diabetes mellitus and disease
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 1.02 Pain Relevance 0
Indeed, the amount of detectable HN in hypothalamus, skeletal muscle, and cortex was decreased with age in rodents, and circulating levels of HN were decreased with age in humans and mice.


Negative_regulation (decreased) of HN in cortex
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.73 Pain Relevance 0

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