INT275752

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
neuronal 2
hepatocytes 2
xn (Mus musculus)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 4 48.60 Quite Low
vagus nerve 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 36 88.96 High High
Obesity 2 84.56 Quite High
Stroke 2 57.24 Quite High
Cognitive Disorder 8 56.60 Quite High
Disease 50 44.12 Quite Low
Amyloid Plaque 2 33.68 Quite Low
Apoptosis 30 30.32 Quite Low
Insulin Resistance 10 25.64 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then tested the effects of HN on primary hepatocytes including its ability to induce phosphorylation of STAT-3, as hepatic STAT-3 activation has been linked to insulin action [29].
HN Positive_regulation (induce) of Phosphorylation (phosphorylation) of STAT-3 in hepatocytes
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.13 Pain Relevance 0
This is in partial agreement with prior studies which have pinpointed the mechanism by which HN confers neuronal protection to the activation of tyrosine kinases and STAT-3 phosphorylation [14].
HN Positive_regulation (confers) of Phosphorylation (phosphorylation) of STAT-3 in neuronal
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.45 Pain Relevance 0

General Comments

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