INT275756

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
third ventricle 1
xn (Mus musculus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 12 19.28 Low Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 150 94.60 High High
Insulin Resistance 30 94.32 High High
Parkinson's Disease 6 93.64 High High
Drug Induced Neurotoxicity 6 92.08 High High
Diabetes Mellitus 108 90.68 High High
Aging 12 90.16 High High
Neurodegenerative Disease 6 83.96 Quite High
Apoptosis 90 83.20 Quite High
Obesity 6 82.40 Quite High
Targeted Disruption 6 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, these data demonstrate for the first time that HN regulates peripheral insulin action.
HN Regulation (regulates) of insulin
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.99 Pain Relevance 0
To assess if IGFBP-3 attenuates the effects of HN on insulin action, we utilized a series of HN analogues that do not bind to IGFBP-3 (Fig. 4A).
HN Regulation (effects) of insulin
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.16 Pain Relevance 0
Thus, intravenous HNGF6A, a more potent analog of HN, is able to reproduce the potent effects of central HN on insulin sensitivity.


HN Regulation (effects) of insulin
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Using state of the art clamp technology, we examined the role of central and peripheral HN on insulin action.
HN Regulation (role) of insulin
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.89 Pain Relevance 0
Likewise, we show that co-infusion of a STAT-3 inhibitor with HN into the third ventricle completely attenuates the ability of HN to modulate peripheral insulin action.
HN Regulation (modulate) of insulin in third ventricle
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.34 Pain Relevance 0
The central effects of HN on insulin action were associated with activation of hypothalamic STAT-3 signaling; effects that were negated by co-inhibition of hypothalamic STAT-3.
HN Regulation (effects) of insulin
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.87 Pain Relevance 0

General Comments

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