INT275797

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.16

endoplasmic reticulum (Hcrt) plasma membrane (Pag1) intracellular (Pag1) cytoplasm (Hcrt)

Hcrt (Mus musculus) Pag1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 16 94.28 amygdala 4 47.04 Hippocampus 1 43.92 Locus ceruleus 10 5.00 Neuropeptide 2 5.00 anesthesia 1 5.00 Dopamine 1 5.00 Raphe 1 5.00 medulla 1 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 40 80.24 Targeted Disruption 15 50.00 Sprains And Strains 15 5.00 Overdose 4 5.00 Generalized Anxiety Disorder 2 5.00 Vibrio Infection 2 5.00 Sarcoma 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering that REM sleep was further increased after vlPAG lesions in HCRT-ko mice is evidence that other non-HCRT input to the vlPAG acts to inhibit REM sleep.

HCRT Binding (input) of vlPAG

1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0.16

General Comments

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