INT275798

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rem1) plasma membrane (Pag1) intracellular (Pag1)
GTPase activity (Rem1) cellular_component (Rem1) biological_process (Rem1)
Anatomy Link Frequency
muscle 1
Pag1 (Mus musculus)
Rem1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 16 30.16 Quite Low
Locus ceruleus 10 27.40 Quite Low
amygdala 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Raphe 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 40 99.56 Very High Very High Very High
Sprains And Strains 15 56.32 Quite High
Targeted Disruption 15 50.00 Quite Low
Overdose 4 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Vibrio Infection 2 5.00 Very Low Very Low Very Low
Sarcoma 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We reasoned that if the vlPAG neurons are important regulators of REM sleep and muscle tone then deletion of both the ligand and the target neurons in the vlPAG should have an additive effect on REM sleep and cataplexy. vlPAG lesion in the HCRT-ko mice increased REM sleep (+39% compared to HCRT-ko; +177% compared to WT), number of bouts of REM sleep, and further fragmented sleep architecture.
vlPAG Regulation (effect) of REM in muscle associated with sleep disorders
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.41 Pain Relevance 0

General Comments

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