INT2758

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Context Info
Confidence 0.44
First Reported 1979
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 8.30
Pain Relevance 14.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dbp)
Anatomy Link Frequency
blood 4
brain 3
neuronal 1
GPI 1
hepatocyte 1
Dbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 20 100.00 Very High Very High Very High
opiate 17 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
fortral 8 100.00 Very High Very High Very High
Gabapentin 8 100.00 Very High Very High Very High
nMDA receptor 7 100.00 Very High Very High Very High
Cannabinoid 5 100.00 Very High Very High Very High
local anesthetic 3 99.98 Very High Very High Very High
Pain 23 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 407 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 6 99.86 Very High Very High Very High
Nicotine Addiction 17 99.60 Very High Very High Very High
Neuropathy 68 99.20 Very High Very High Very High
Stroke 50 98.96 Very High Very High Very High
Alzheimer's Dementia 2 98.34 Very High Very High Very High
Diabetes Mellitus 27 98.32 Very High Very High Very High
Death 22 98.32 Very High Very High Very High
Leukemia 1 97.36 Very High Very High Very High
Pain 17 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the GLM of tolerance also produced a significant drug by DBP interaction suggesting that blood pressure-related analgesia is at least partially opioid-mediated.
DBP Binding (interaction) of in blood associated with tolerance, opioid and analgesia
1) Confidence 0.44 Published 2008 Journal Pain Section Abstract Doc Link 17560720 Disease Relevance 0.43 Pain Relevance 1.32
Medical practitioners have been slow to recognize DBP, and there has been little research into the spiritual effect that DBP have on caregivers or on how these phenomena influence their work.
DBP Binding (recognize) of
2) Confidence 0.42 Published 2006 Journal Am J Hosp Palliat Care Section Abstract Doc Link 16450659 Disease Relevance 0.19 Pain Relevance 0.21
Results of the interviews raise concerns about the lack of education or training to help palliative care teams recognize the wider implications of DBP and deal with difficult questions or situations associated with them.
DBP Binding (recognize) of associated with palliative
3) Confidence 0.31 Published 2006 Journal Am J Hosp Palliat Care Section Abstract Doc Link 16450659 Disease Relevance 0.14 Pain Relevance 0.26
In Greenlanders adults, mercury in blood was associated with reduced DBP and increased PP [9].
DBP Binding (associated) of in blood
4) Confidence 0.30 Published 2008 Journal Environ Health Section Body Doc Link PMC2443124 Disease Relevance 0.05 Pain Relevance 0
A main effect of solution on tolerance was seen in the GLM with DBP, which was qualified by an interaction of solution by blood pressure.
DBP Binding (interaction) of in blood associated with tolerance
5) Confidence 0.29 Published 2008 Journal Pain Section Abstract Doc Link 17560720 Disease Relevance 0.50 Pain Relevance 1.14
These and additional data suggest that the binding of [3H]bremazocine to the kappa binding site of rat brain is optimally assayed at 0 degrees C in the presence of 0.4 M NaCl using BIT/FIT-treated membranes and that rat brain is endowed with a high level of kappa binding sites.
binding site Binding (binding) of in brain
6) Confidence 0.28 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3001575 Disease Relevance 0 Pain Relevance 0.14
Membranes were pretreated with mu-selective (BIT) and delta-selective (FIT) site-directed acylating agents (Rice et al., Science 220, 314-316), and the binding of [3H]bremazocine to the residual binding sites was defined as the kappa binding site.
binding site Binding (binding) of
7) Confidence 0.28 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3001575 Disease Relevance 0 Pain Relevance 0.17
NB bound to the mu-binding site with affinity higher than that of pentazocine and to the kappa-binding site with the lowest affinity.
kappa-binding site Binding (bound) of associated with fortral
8) Confidence 0.24 Published 1983 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6321306 Disease Relevance 0 Pain Relevance 1.44
NB bound to the mu-binding site with affinity higher than that of pentazocine and to the kappa-binding site with the lowest affinity.
mu-binding site Binding (bound) of associated with fortral
9) Confidence 0.24 Published 1983 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6321306 Disease Relevance 0 Pain Relevance 1.37
Master circadian regulators Clock and Arntl/Bmal1 (aryl hydrocarbon receptor nuclear translocator-like) control the expression of the PARbZip family of transcription factors which is comprised of three members: Dbp (albumin site D-binding protein), Tef (thyrotroph embryonic factor), and Hlf (hepatocyte leukemia factor).
Dbp Binding (binding) of in hepatocyte associated with leukemia
10) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.30 Pain Relevance 0
Since yohimbine previously has been demonstrated to interfere both with noradrenaline (NA) and serotonin (5-HT) neurochemistry, and, in addition, shows affinity for the BDZ binding site, we have focused on the putative involvement of these neuronal systems in the yohimbine-induced anticonflict effect.
BDZ binding site Binding (affinity) of in neuronal associated with noradrenaline and serotonin
11) Confidence 0.23 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8748665 Disease Relevance 0 Pain Relevance 0.45
Studies from Europe have also demonstrated a positive continuous, graded, and independent association for both total (P<. 001) and cardiovascular (P< .001) mortality with SBP but not DBP.
DBP Binding (association) of
12) Confidence 0.22 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.02 Pain Relevance 0
The data do not support previous indications of an association of the gabapentin binding site and NMDA/glycine receptor complex.
gabapentin binding site Binding (association) of associated with gabapentin
13) Confidence 0.20 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8384571 Disease Relevance 0 Pain Relevance 0.68
Guidelines recommend initiation of combination therapy when diastolic blood pressure (DBP) values are ?
DBP Binding (recommend) of in blood
14) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663442 Disease Relevance 0.56 Pain Relevance 0.03
In another study, lowering DBP (< 65-70 mmHg) in the course of treating ISH may be associated with an increase risk of stroke and other cardiovascular events [69].


DBP Binding (associated) of associated with stroke and hypertension
15) Confidence 0.17 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.05 Pain Relevance 0.14
These data indicate that the ability of PCP analogs to inhibit epinephrine-stimulated aggregation is not related to their ability to bind to the high affinity platelet PCP binding site.
PCP binding site Neg (not) Binding (bind) of in platelet
16) Confidence 0.15 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7981230 Disease Relevance 0 Pain Relevance 0.22
The present study, therefore, establishes a role for the kappa binding site in thermal analgesia in the tail flick test and differentiates its ontogenetic pattern from that of the mu receptor.
binding site Binding (role) of in tail associated with tail-flick and analgesia
17) Confidence 0.11 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021285 Disease Relevance 0.08 Pain Relevance 0.85
The cannabinoid agonist WIN55212-2 has a 25-fold lower affinity for [3H]SR141716A than for [3H]WIN55212-2, showing that the two ligands do not recognize the cannabinoid binding site in the same fashion.
cannabinoid binding site Neg (not) Binding (recognize) of associated with cannabinoid and agonist
18) Confidence 0.10 Published 1996 Journal Neuroreport Section Abstract Doc Link 8733746 Disease Relevance 0 Pain Relevance 0.30
These results suggested that the MS-377 selectively binds to sigma binding site with high affinity in rat brain membranes.
sigma binding site Binding (binds) of in brain
19) Confidence 0.10 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10913584 Disease Relevance 0 Pain Relevance 0.23
Eel calcitonin binding site distribution and antinociceptive activity in rats.
calcitonin binding site Binding (binding) of associated with pain and antinociceptive
20) Confidence 0.08 Published 1986 Journal Peptides Section Title Doc Link 3016684 Disease Relevance 0 Pain Relevance 0.39

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