INT275803

Context Info Confidence 0.19 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.10

signal transduction (Rem1) endoplasmic reticulum (Hcrt) GTPase activity (Rem1) cellular_component (Rem1) biological_process (Rem1) cytoplasm (Hcrt)

Anatomy Link Frequency neurons 1 Hcrt (Mus musculus) Rem1 (Mus musculus)

Pain Link Frequency Relevance Heat amygdala 4 76.00 Locus ceruleus 10 73.56 gABA 16 5.00 Neuropeptide 2 5.00 anesthesia 1 5.00 Dopamine 1 5.00 Raphe 1 5.00 Hippocampus 1 5.00 medulla 1 5.00

Disease Link Frequency Relevance Heat Sleep Disorders 40 95.48 Sarcoma 1 74.32 Targeted Disruption 15 50.00 Vibrio Infection 2 37.68 Sprains And Strains 15 5.00 Overdose 4 5.00 Generalized Anxiety Disorder 2 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since the effects were exacerbated in HCRT-ko mice, the vlPAG neurons receive other excitatory inputs, besides HCRT which serves to inhibit REM sleep.

HCRT Negative_regulation (inhibit) of REM in neurons

1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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