INT275803

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rem1) endoplasmic reticulum (Hcrt) GTPase activity (Rem1)
cellular_component (Rem1) biological_process (Rem1) cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 1
Hcrt (Mus musculus)
Rem1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 4 76.00 Quite High
Locus ceruleus 10 73.56 Quite High
gABA 16 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Raphe 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 40 95.48 Very High Very High Very High
Sarcoma 1 74.32 Quite High
Targeted Disruption 15 50.00 Quite Low
Vibrio Infection 2 37.68 Quite Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the effects were exacerbated in HCRT-ko mice, the vlPAG neurons receive other excitatory inputs, besides HCRT which serves to inhibit REM sleep.
HCRT Negative_regulation (inhibit) of REM in neurons
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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