INT275828

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr1) plasma membrane (Tlr1) intracellular (Tlr1)
Tlr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 79 77.76 Quite High
cytokine 43 76.72 Quite High
Multiple sclerosis 4 6.60 Low Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Latent Tuberculosis 6 98.60 Very High Very High Very High
Infection 61 97.84 Very High Very High Very High
Mycobacterial Infection 71 97.44 Very High Very High Very High
Shock 4 82.48 Quite High
INFLAMMATION 82 77.76 Quite High
Lymphatic Filariasis 7 66.16 Quite High
Syndrome 1 62.40 Quite High
Disease 40 27.00 Quite Low
Atherosclerosis 3 20.96 Low Low
Cancer 3 20.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, TLR1 was shown for the first time to be required, along with TLR2, for the activation of professional antigen-presenting cells by ?
Positive_regulation (activation) of Gene_expression (shown) of TLR1
1) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.39 Pain Relevance 0.12
By analyzing the baseline and mycobacterial antigen–stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection), we were able to demonstrate that filarial infection, coincident with Mtb, significantly diminishes both baseline and Mtb antigen-specific TLR2 and TLR9 expression.
Positive_regulation (stimulated) of Gene_expression (expression) of TLR1 associated with mycobacterial infection, latent tuberculosis and infection
2) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2710006 Disease Relevance 1.36 Pain Relevance 0.14

General Comments

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